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Fatty acids composition in yellow-legged (Larus michahellis) and lesser black-b...
Lopes, Catarina S.; Antunes, Raquel C. C.; Paiva, Vitor H.; Goncalves, Ana M. M.; Correia, Jorge Manuel de Jesus; Ramos, Jaime A.Urban habitats offer spatially and temporally predictable anthropogenic food sources for opportunistic species, such as several species of gulls that are known to exploit urban areas and take advantage of accessible and diverse food sources, reducing foraging time and energy expenditure. However, human-derived food may have a poorer nutritional quality than the typical natural food resources and foraging in urb...
HER2-Targeted immunotherapy and combined protocols showed promising antiprolife...
Gameiro, Andreia; Nascimento, Catarina; Correia, Jorge Manuel de Jesus; Ferreira, FernandoABSTRACT - Feline mammary carcinoma (FMC) is a highly prevalent tumor, showing aggressive clinicopathological features, with HER2-positive being the most frequent subtype. While, in human breast cancer, the use of anti-HER2 monoclonal antibodies (mAbs) is common, acting by blocking the extracellular domain (ECD) of the HER2 protein and by inducing cell apoptosis, scarce information is available on use these imm...
Serum and tissue expression levels of leptin and leptin receptor are putative m...
Gameiro, Andreia; Nascimento, Catarina; Urbano, Ana Catarina; Correia, Jorge Manuel de Jesus; Ferreira, FernandoABSTRACT - Obesity is an established risk factor for breast cancer in post-menopausal women, being associated with elevated serum levels of leptin. Although overweight is a common condition in cat, the role of leptin and its receptor in feline mammary carcinoma remains unsettled. In this study, serum leptin and leptin receptor (ObR) levels were investigated in 58 cats with mammary carcinoma and compared with th...
Tyrosine kinase inhibitors are promising therapeutic tools for cats with HER2-p...
Gameiro, Andreia; Almeida, Filipe; Nascimento, Catarina; Correia, Jorge Manuel de Jesus; Ferreira, FernandoABSTRACT - Feline mammary carcinoma (FMC) is a common neoplasia in cat, being HER2-positive the most prevalent subtype. In woman’s breast cancer, tyrosine kinase inhibitors (TKi) are used as a therapeutic option, by blocking the phosphorylation of the HER2 tyrosine kinase domain. Moreover, clinical trials demonstrated that TKi produce synergistic antiproliferative effects in combination with mTOR inhibitors, ov...
Histone deacetylase inhibitors and microtubule inhibitors induce apoptosis in f...
Almeida, Filipe; Gameiro, Andreia; Correia, Jorge Manuel de Jesus; Ferreira, FernandoSimple Summary: Feline mammary tumors (FMT) are very common in cats, associated with very aggressive behavior and a short life expectancy. Surgery is the most used treatment but tumor recurrence is common. Currently, available therapies are insufficient, therefore, new molecular targets are needed to develop more efficient therapeutics. Histone deacetylases inhibitors (HDACis) have been developed to target tumo...
Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma
Nascimento, Catarina; Gameiro, Andreia; Ferreira, Fernando; Correia, Jorge Manuel de Jesus; Ferreira, JoãoVascular endothelial growth factor (VEGF-A) plays an essential role in tumor-associated angiogenesis, exerting its biological activity by binding and activating membrane receptors, as vascular endothelial growth factor receptor 1 and 2 (VEGFR-1, VEGFR-2). In this study, serum VEGF-A, VEGFR1, and VEGFR-2 levels were quantified in 50 cats with mammary carcinoma and 14 healthy controls. The expression of these mol...
Anaplastic mammary carcinoma in cat
Soares, Maria; Correia, Jorge Manuel de Jesus; Nascimento, Catarina; Ferreira, FernandoClinical, pathological, and immunohistochemical findings related to a feline mammary tumor with similar features to canine anaplastic mammary carcinoma are herein described for the first time. A female cat was presented for clinical evaluation with gastrointestinal signs, oedema, erythema, and painful lesion in the right inguinal region. Three weeks later, the mass had doubled in size and radiographic revaluati...
Influence of dietary supplementation with an amino acid mixture on inflammatory...
Prates, José A.M; Freire, João; Almeida, André; Martins, Cátia Falcão; Ribeiro, David M.; Osorio, Hugo; Pinho, Mário; Lopes, Paula AlexandraIn order to investigate the effect of a dietary amino acid mixture supplementation in lipopolysaccharide (LPS)-challenged weaned piglets, twenty-seven 28-day-old (8.2 ± 1.0 kg) newly weaned piglets were randomly allocated to one of three experimental treatments for five weeks. Diet 1: a CTRL treatment. Diet 2: an LPS treatment, where piglets were intraperitoneally administered LPS (25 μg/kg) on day 7. Diet 3: a...
Serum PD-1/PD-L1 levels, tumor expression and PD-L1 somatic mutations in HER2-p...
Nascimento, Catarina; Urbano, Ana Catarina; Gameiro, Andreia; Ferreira, João; Correia, Jorge Manuel de Jesus; Ferreira, FernandoTumor microenvironment has gained great relevance due to its ability to regulate distinct checkpoints mediators, orchestrating tumor progression. Serum programmed cell death protein-1 (PD-1) and programmed death ligand-1 (PD-L1) levels were compared with healthy controls and with serum cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and tumor necrosis factor-alpha (TNF-α) levels in order to understand the ...
Meglumine antimoniate and miltefosine combined with allopurinol sustain pro-inf...
Santos, Marcos André Ferreira; Alexandre-Pires, Graça; Pereira, Maria A.; Marques, Cátia Filipa Saraiva; Gomes, Joana; Correia, Jorge Manuel de JesusCanine leishmaniosis (CanL) caused by Leishmania infantum is a zoonotic disease of global concern. Antileishmanial drug therapies commonly used to treat sick dogs improve their clinical condition, although when discontinued relapses can occur. Thus, the current study aims to evaluate the effect of CanL treatments in peripheral blood, lymph node, and bone marrow cytokine profile associated with clinical recovery...