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Transanal total mesorectal excision: a pure NOTES approach for selected patients

Leão, P; Goulart, A; Veiga, C; Cristino, H; Marcos, N; Correia-Pinto, J; Rodrigues, M; Moreno-Sanz, C

The concept of natural orifice transluminal endoscopic surgery (NOTES) has stimulated the development of various "incisionless" procedures. One of the most popular is the transanal approach for rectal lesions. The aims of this study were to report how we standardized NOTES technique for transanal mesorectal excision without abdominal assistance, discuss the difficulties and surgical outcomes of this technique a...


Helicobacter pylori chronic infection and mucosal inflammation switches the hum...

Magalhães, A; Marcos-Pinto, R; Nairn, A; dela Rosa, M; Ferreira, RM; Junqueira-Neto, S; Freitas, DP; Gomes, J; Oliveira, P; Santos, M; Marcos, N

Helicobacter pylori exploits host glycoconjugates to colonize the gastric niche. Infection can persist for decades promoting chronic inflammation, and in a subset of individuals lesions can silently progress to cancer. This study shows that H. pylori chronic infection and gastric tissue inflammation result in a remodeling of the gastric glycophenotype with increased expression of sialyl-Lewis a/x antigens due t...


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