7 documents found, page 1 of 1

Alterations in mucosa branched N-glycans lead to dysbiosis and downregulation o...

The perturbation of the symbiotic relationship between microbes and intestinal immune system contributes to gut inflammation and Inflammatory Bowel Disease (IBD) development. The host mucosa glycans (glycocalyx) creates a major biological interface between gut microorganisms and host immunity that remains ill-defined. Glycans are essential players in IBD immunopathogenesis, even years before disease onset. Howe...

Helicobacter pylori lipopolysaccharide structural domains and their recognition...

The structural diversity of the lipopolysaccharides (LPSs) from Helicobacter pylori poses a challenge to establish accurate and strain-specific structure-function relationships in interactions with the host. Here, LPS structural domains from five clinical isolates were obtained and compared with the reference strain 26695. This was achieved combining information from structural analysis (GC-MS and ESI-MSn) with...

Metabolic control of T cell immune response through glycans in inflammatory bow...

Mucosal T lymphocytes from patients with ulcerative colitis (UC) were previously shown to display a deficiency in branched N-glycosylation associated with disease severity. However, whether this glycosylation pathway shapes the course of the T cell response constituting a targeted-specific mechanism in UC remains largely unknown. In this study, we demonstrated that metabolic supplementation of ex vivo mucosal T...

Training in endoscopic mucosal resection and endoscopic submucosal dissection: ...

Introduction: Endoscopic mucosal resection and endoscopic submucosal dissection are demanding procedures. This study aims to establish face, content and expert validity of the live porcine model in performing endoscopic mucosal resection, endoscopic submucosal dissection, complication management and to assess it as a training tool. Material and methods: Tutors and trainees participating in live porcine model en...

Metabolic control of T cell immune response through glycans in inflammatory bow...

Mucosal T lymphocytes from patients with ulcerative colitis (UC) were previously shown to display a deficiency in branched N-glycosylation associated with disease severity. However, whether this glycosylation pathway shapes the course of the T cell response constituting a targeted-specific mechanism in UC remains largely unknown. In this study, we demonstrated that metabolic supplementation of ex vivo mucosal T...

N-glicosilação do recetor das células t: um novo mecanismo molecular na patogén...

Gastric Cancer: An Opportunity for Prevention

Gastric cancer is one of the most prevalent cancers worldwide, ranking fourth after lung, breast and colorectal cancers, and it is the second cause of cancer death. The majority of cases occur in developing countries and are more common in males, irrespective of age and geographic area. In Portugal it ranks fifth in cancer deaths and its incidence is the highest in Western Europe.