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Ketamine combined with psychotherapy for treatment-resistant depression

Cohen, Rebeca; Bastos, João; Cunha, Catarina; Marguilho, Miriam; Sancho, Ana; Silva, Maria João Matos; King, Franklin; Castro-Rodrigues, Pedro

Ketamine, an N -methyl- d -aspartate antagonist, shows promise for treatment-resistant depression (TRD), with psychedelic doses potentially enhancing efficacy. However, its transient antidepressant effects and the need for repeated infusions raise concerns about optimal duration and long-term safety. Two clinical trials have tested the combination of ketamine with psychotherapy for depression, with mixed result...


Proposal to conduct an eight-session mindfulness-based CBT intervention for wom...

Manão, Andreia Alexandra; Gonçalves, Marco; Marguilho, Miriam; Fernandes, Carlos; Pablo, Cristina

Introduction: Sexual problems and dysfunctions can be distressing and harm both psychological and physical health. Low sexual desire is a common sexual problem among women, with research indicating that it affects up to one-third of them. Studies and expert guidelines (e.g., International Consultation on Sexual Medicine) emphasise that mindfulness-based treatments have strong evidence for effectively addressing...


Gender Dysphoria: Concepts, Diagnosis and Clinical Management

Alves Rodrigues, Carolina; Marguilho, Miriam; Ferreira, Bárbara; Nascimento, Sandra; Nascimento, Miguel; Cardoso, Sónia; Silva, Mariana

Gender dysphoria is defined as a condition characterized by mental suffering associated with the incongruence between one’s experienced gender and their birth-assigned sex. Gender as a construct and gender dysphoria as a condition in need of multidisciplinary intervention have developed as swiftly as their visibility in society, making it mandatory to promote the literacy and education of all healthcare profess...

Date: 2024   |   Origin: Acta Médica Portuguesa

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