12 documents found, page 1 of 2

Antimicrobial and antibiofilm effect of phytochemicals as a potential treatment...

The treatment of bacterial infections has been troubled by the increased resistance to antibiotics [1, 2]. Thus, it is crucial to discover novel and effective therapies to control and eradicate planktonic and sessile bacterial cells [3]. Phytochemicals have demonstrated broad-spectrum and effective antibacterial effects as well as antibiotic resistance-modifying activity [4]. In this study, perillyl alcohol and...

Biofilms in Diabetic Foot Ulcers: Impact, Risk Factors and Control Strategies

Diabetic foot ulcers (DFUs) are a serious complication from diabetes mellitus, with a huge economic, social and psychological impact on the patients' life. One of the main reasons why DFUs are so difficult to heal is related to the presence of biofilms. Biofilms promote wound inflammation and a remarkable lack of response to host defences/treatment options, which can lead to disease progression and chronicity. ...

Virulence, attachment and invasion of Caco-2 cells by multidrug-resistant bacte...

Wild animals may be considered important reservoirs for bacterial pathogens and, consequently, possible sources of infection for humans In this study, selected multidrug-resistant bacteria (Acinetobacter spp., Aeromonas salmonicida, Klebsiella pneumoniae, Pseudomonas fluorescens and Shewanella putrefaciens) isolated from wild animals were characterized on their ability to attach and invade/internalize human col...

Biofilm formation and multidrug-resistant Aeromonas spp. from wild animals

Objectives: The 'One Health' concept recognises that the health of humans, animals and the environment are interconnected. Therefore, knowledge on the behaviour of micro-organisms from the most diverse environmental niches is important to prevent the emergence and dissemination of antimicrobial resistance. Wild animals are known to carry antimicrobial-resistant micro-organisms with potential public health impac...

Biofilms and antibiotic susceptibility of multidrug-resistant bacteria from wil...

Background. The "One Health" concept recognizes that human health and animal health are interdependent and bound to the health of the ecosystem in which they (co)exist. This interconnection favors the transmission of bacteria and other infectious agents as well as the flow of genetic elements containing antibiotic resistance genes. This problem is worsened when pathogenic bacteria have the ability to establish ...

New Perspectives on the Use of Phytochemicals as an Emergent Strategy to Contro...

The majority of current infectious diseases are almost untreatable by conventional antibiotic therapy given the advent of multidrug-resistant bacteria. The degree of severity and the persistence of infections are worsened when microorganisms form biofilms. Therefore, efforts are being applied to develop new drugs not as vulnerable as the current ones to bacterial resistance mechanisms, and also able to target b...

Combinatorial approaches with selected phytochemicals to increase antibiotic ef...

Combinations of selected phytochemicals (reserpine, pyrrolidine, quinine, morin and quercetin) with antibiotics (ciprofloxacin, tetracycline and erythromycin) were tested on the prevention and control of Staphylococcus aureus biofilms. The phytochemicals were also studied for their ability to avoid antibiotic adaptation and to inhibit antibiotic efflux pumps. Morin, pyrrolidine and quercetin at subinhibitory co...

Combinatorial Activity of Flavonoids with Antibiotics Against Drug-Resistant St...

The use of resistance-modifying agents is a potential strategy that is used to prolong the effective life of antibiotics in the face of increasing antibiotic resistance. Since certain flavonoids are potent bacterial efflux pump inhibitors, we assessed morin, rutin, quercetin, hesperidin, and (+)-catechin for their combined activity with the antibiotics ciprofloxacin, tetracycline, erythromycin, oxacillin, and a...

Evaluation of the best method to assess antibiotic potentiation by phytochemica...

The increasing occurrence of bacterial resistance to antibiotics has now reached a critical level. Finding antibiotic coadjuvants capable to inhibit the bacterial resistance mechanisms would be a valuable mid-term solution, until new classes of antibiotics are discovered. Selected plant alkaloids were combined with 5 antibiotics against 10 Staphylococcus aureus strains, including strains expressing distinct eff...

Extended-spectrum beta-lactamase and carbapenemase-producing Aeromonas 1 spp. i...