5 documents found, page 1 of 1
Association between Diethyl Phthalate (DEP) exposure and hypertension in pregna...
Mariana, Melissa; Soares, Amadeu M.; Castelo-Branco, Miguel; Cairrao, ElisaBackground: Hypertensive disorders in pregnancy are one of the leading causes of gestational morbidity and mortality [1]. Several risk factors have already been identified, such as a sedentary lifestyle, advanced age, alcohol and tobacco consumption, and familial predisposition, but a new one is gaining prominence due to its high presence in our daily lives, which is exposure to environmental contaminants. Bein...
Phthalates’ exposure leads to an increasing concern on cardiovascular health
Mariana, Melissa; Castelo-Branco, Miguel; Soares, Amadeu M.; Cairrao, ElisaBeing an essential component in the plastics industry, phthalates are ubiquitous in the environment and in everyday life. They are considered environmental contaminants that have been classified as endocrine-disrupting compounds. Despite di-2-ethylhexyl phthalate (DEHP) being the most common plasticizer and the most studied to date, there are many others that, in addition to being widely used in the plastic, ar...
Vascular mechanisms of testosterone: the non-genomic point of view
Lorigo, Margarida; Mariana, Melissa; Lemos, Manuel C.; Cairrão, ElisaTestosterone (T) is the predominant endogenous androgen in the bloodstream. At the vascular level, T presents genomic and non-genomic effects, and both effects may overlap. The genomic actions assume that androgens can freely cross the plasma membrane of target cells and bind to nuclear androgen receptors, inducing gene transcription and protein synthesis. The non-genomic effects have a more rapid onset and may...
Vascular Pathways of Testosterone: Clinical Implications
Lorigo, Margarida; Mariana, Melissa; Oliveira, Nelson; Lemos, Manuel C.; Cairrão, ElisaCardiovascular diseases (CVD) are one of the leading causes of death worldwide. Testosterone (T) is an important sex hormone that triggers several genomic and non-genomic pathways, leading to improvements of several cardiovascular risk factors and quality of life in men. At the vascular level, the key effect of T is the vasorelaxation. This review discusses the molecular pathways and clinical implications of T ...
Effects of Di-(2-ethylhexyl) phthalate on vascular smooth muscle cells
Mariana, Melissa; Cairrão, Elisa; Verde, IgnacioEvery year million tons of plastic are produced around the world and humans are increasingly exposed to them. This constant exposure has raised some concerns against human health and substances leaching from plastics, such as phthalates. These compounds, used to give flexibility to polyvinyl chloride (PVC), are endocrine-disrupting compounds because they have the ability to interfere with hormone pathways. Phth...