24 documents found, page 1 of 3
Impact of the 2022 ATS/ERS update criteria on the bronchodilator responsiveness...
Martins, B.; Marinho, A.; Amorim, PedroBronchodilator response (BDR) is a measurement of the degree of volume and airflow improvement in response to an inhaled short-acting bronchodilator. It is widely used in clinical practice to diagnose respiratory diseases such as chronic obstructive pulmonary disease (COPD) or asthma, to assess asthma control, and predict the response to inhaled treatment.
Characterisation of yeast flora isolated from an artisanal Portuguese ewes’ cheese
Pereira-Dias, S.; Potes, M.E.; Marinho, A.; Malfeito-Ferreira, M.; Loureiro, V.The evolution of the yeast flora was studied for an artisanal semi-hard ewes’ cheese made from raw milk. Mean log10 yeast counts per gram of cheese body ranged from 2.7 to 6.4, with the higher counts observed after a ripening period of 30 days. The yeast population decreased thereafter and, at the end of curing process, reached values similar to those of the beginning. A total of 344 yeasts strains were randoml...
Mycoplasma e Ureaplasma. Microbiologia Médica – Vol.1
Saavedra, M. J.; Marinho, A.; Duarte, A.Os micoplasmas, organismos que integram a classe Mollicutis, constituem um vasto grupo de procariotas que se diferenciam das outras bactérias pelo seu pequeno tamanho celular, pela falta de parede celular e pelas dimensões reduzidas do seu genoma. Mycoplasma e Ureoplasma são os géneros com maior importância médica, com algumas das suas espécies envolvidas em pneumonias, infeções urinárias e artrites no Homem. A...
Princípios Gerais de Bacteriologia. Microbiologia Médica – Vol. 1
Marinho, A.; Taveira, N.As bactérias são procariotas que pertencem ao domínio Bacteria e apresentam três formas básicas: esférica, cilíndrica e helicoidal. As células podem associar-se, formando arranjos característicos de alguns géneros bacterianos. A parede celular, além de conferir forma às bactérias, é responsável pela diferenciação entre bactérias Gram-positivo e Gram-negativo. Além disso, é um alvo preferencial para a atuação de...
Association between vitamin D receptor (VDR) gene polymorphisms and systemic lu...
Carvalho, C.; Marinho, A.; Leal, B.; Bettencourt, A.; Boleixa, D.; Almeida, I.; Farinha, F.; Costa, P.P.; Vasconcelos, C.; Silva, B.M.Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown origin, in which both genetic and environmental factors are involved. One such environmental factor is vitamin D, a vital hormone that plays a specific function in the immune system homeostasis, acting through a nuclear receptor (VDR) expressed in all immune cells. Several polymorphisms of the gene that encodes this receptor have been...
A nossa regra de ouro na doença de Behçet: tratar a manifestação clínica
Ferrão, C.; Almeida, I.; Marinho, A.; Vasconcelos, C.; Correia, J.A Doença de Behçet (DB) é uma vasculite sistémica que pode ser definida na fronteira entre a doença autoimune e autoinflamatória. A sua etiopatogenia ainda não é completamente conhecida, embora saibamos que contribuem factores genéticos (Antigénios de Histocompatibilidade/ HLA, por exemplo) e ambienciais (maior prevalência em zonas específicas do globo). Há células implicadas no processo patológico (neutrófilos...
The Protective Role of HLA-DRB1(∗)13 in Autoimmune Diseases
Bettencourt, A.; Carvalho, C.; Leal, B.; Brás, S.; Lopes, D.; Martins da Silva, A.; Santos, E.; Torres, T.; Almeida, I.; Farinha, F.; Barbosa, P.Autoimmune diseases (AIDs) are characterized by a multifactorial aetiology and a complex genetic background, with the MHC region playing a major role. We genotyped for HLA-DRB1 locus 1228 patients with AIDs-213 with Systemic Lupus Erythematosus (SLE), 166 with Psoriasis or Psoriatic Arthritis (Ps + PsA), 153 with Rheumatoid Arthritis (RA), 67 with Systemic Sclerosis (SSc), 536 with Multiple Sclerosis (MS), and ...
Recomendações para o Diagnóstico da Forma Tardia da Doença de Pompe
Brito-Avô, L.; Alves, J.; Costa, J.; Valverde, A.; Santos, L.; Araújo, F.; Marinho, A.; Oliveira, A.; Gomes, D.INTRODUCTION: Pompe disease is a progressive and debilitating autossomal recessive myopathy due to mutations in lysossomal acid-α-glucosidase. Its late-onset form has a heterogeneous presentation mimicking other neuromuscular diseases, leading to diagnostic challenge. OBJECTIVE: To develop consensus based recommendations for the diagnosis of late-onset Pompe Disease. MATERIAL AND METHODS: Bibliographic review a...
CCR5-Delta32: Implications in SLE development
Carvalho, C.; Calvisi, S.L.; Leal, B.; Bettencourt, A.; Marinho, A.; Almeida, I.; Farinha, F.; Pinho-Costa, P.; Silva, B.M.; Vasconcelos, C.Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease with strong genetic and environmental components. Previous studies have shown increased levels of several chemokines in active SLE. C-C chemokine receptor type 5 (CCR5) is involved in the recruitment of inflammatory cells into tissues, and mechanisms modulating CCR5 expression and function may interfere in SLE development, influencing the c...
Estimating Kidney Function in the Critically Ill Patients
Seller-Pérez, G.; Herrera-Gutiérrez, M.; Maynar-Moliner, J.; Sánchez-Izquierdo-Riera, J.; Marinho, A.; do Pico, J.Glomerular filtration rate (GFR) is an accepted measure for assessment of kidney function. For the critically ill patient, creatinine clearance is the method of reference for the estimation of the GFR, although this is often not measured but estimated by equations (i.e., Cockroft-Gault or MDRD) not well suited for the critically ill patient. Functional evaluation of the kidney rests in serum creatinine (Crs) th...