18 documents found, page 1 of 2
Recommendations for Herpes Zoster Vaccination: Consensus Report from the Portug...
Duque, Sofia; Marinho, António; Almeida , Paulo; Marques Pereira, Raul; Buzaco, RuiHerpes zoster (HZ), or shingles, is caused by the reactivation of the latent varicella zoster virus. It is a high-incidence disease, associated with great morbidity, which might create or worsen a patient’s frailty condition, thus reinforcing the importance of vaccination. Among the risk factors for HZ infection and postherpetic neuralgia (PHN), its major complication, are age, immunosuppression and the presenc...
Campylobacter jejuni Pericarditis: A Case Report
Neves-Maia, Joao; Gomes, Catarina; Marinho, António; Alves, RuteCampylobacter jejuni is one of the most common causes of enteritis. In rare cases, extraintestinal infection can occur, with a handful of cases of cardiac involvement, of which the pathophysiological mechanism is unclear. We report a case of pericarditis in a patient with X-linked agammaglobulinemia presenting with chronic diarrhea and chest pain who evolved to cardiac tamponade, requiring a pericardial window ...
Neuromyotonia: Remembering a Rare Pathology
Martins, Sara Raquel; Xavier Pires, Sara; Marinho, AntónioNeuromyotonia is an exceedingly rare disease. In most cases it seems to be acquired, with a probable autoimmune origin. It is characterized by peripheral nerve hyperexcitability with muscle hyperactivity and deficient relaxation, and it is frequently accompanied by autonomic and sensitive symptoms. The diagnosis is established by electromyography, showing spontaneous, multiple single motor unit discharges, firi...
Window of Opportunity for Immunodulatory Therapy in COVID-19
Faria, Raquel; Carvalheiras, Graziela; Alves, Rute; G. Oliveira, Daniel; Brandão, Mariana; Vita, Pedro; Marinho, AntónioThe COVID-19 pandemic is a serious public health problem worldwide, for which there is no effective therapies. About 20%-33% of patients are admitted to intensive care units and in these the mortality rate is higher than 25%. Death caused directly by the COVID-19 results, in most cases, from an inappropriate hyperinflammatory response to the infection, with the release of cytokines. Due to the parallelism with ...
Biologics Drugs in Behçet’s Disease: A Single Centre Experience
Serpa Pinto, Luísa; Xavier Pires, Sara; Carvalheiras, Graziela; Campar, Ana; Marinho, António; Farinha, Fátima; Vasconcelos, CarlosIntroduction: Behçet´s disease (BD) is a systemic vasculitis of unknown cause. Several cytokines, such as tumor necrosis factor-alpha (TNF-α), appear to play a substantial role. Therefore, biologics such as anti-TNF-α agents are rising to control severe or refractory BD´s manifestations. We aimed to describe the biological therapy´s outcomes in BD patients. Methods: A longitudinal, prospective, un...
Behçet's Disease and Pregnancy: A Retrospective Case-control Study
Barros, Tânia; Braga, António; Marinho, António; Braga, JorgeBackground: Behçet's disease (BD) is a rare chronic multisystemic vasculitis of unknown etiology. It is usually diagnosed between the 2nd and 4th decades of life, so its association with pregnancy is not unusual. This study aims to characterize the evolution of pregnancy in a group of pregnant women with BD and the impact of this pathology in embryo-fetal morbidity. Methods: A retrospective case-control study i...
Secukinumab on Refractory Lupus Nephritis
Costa, Rita; Antunes, Paula; Salvador, Pedro; Oliveira, Pedro; Marinho, AntónioLupus nephritis (LN) is the most frequent severe organ manifestation of systemic lupus erythematosus (SLE). About 30% of patients are refractory to treatment. The authors report a case of treatment of LN with interleukin-17-targeted therapy, demonstrating its possible benefit, after reports of T helper 17 cell involvement in SLE pathogenesis. We present the case of a childbearing age woman with SLE, who develop...
Relational contracting and its combination with the BIM methodology in mitigati...
Marinho, António; Couto, J. Pedro; Teixeira, José M. CardosoProject management in the construction sector is a complex and uncertain process and companies tend to look for the lowest value in the procurement of services and materials. However, contractors do not share the necessary information with the contracted parties and thus give rise to the asymmetric information (AI) phenomenon. The aim of this study is to perform an analysis of the determining factors in the ado...
Not All ENT Granulomas Are Wegener’s – Keep Tuberculosis in Mind
Pedro, Bárbara; Meleiro, Marta; Marinho, AntónioMycobacterium tuberculosis affects the middle ear in rare cases and is a challenging diagnosis. In this case, we present a 57-year-old patient diagnosed with anti-neutrophil cytoplasmic antibody (ANCA)-negative granulomatosis with polyangiitis (GPA) following a biopsy result of nasal granulomas, who was immediately started on immunosuppressive treatment. Years later, she developed progressive hypoacusis. Magnet...
Inclusion Body Myositis Treated with Alemtuzumab
Sá, J.; Costelha, J.; Marinho, Antónionclusion body myositis (IBM) is a chronic inflammatory myopathy with a progressive course. It is more common in the later years of life and usually presents with limb weakness. We present the case of a patient who developed proximal weakness in the lower limbs and, four years later, facial asymmetry. Blood analysis revealed high lactate dehydrogenase and creatinine kinase values. The diagnosis was obtained thro...