36 documents found, page 1 of 4
Ongoing outbreak of hepatitis A associated with sexual transmission among men w...
Rosendal, Ebba; von Schreeb, Sebastian; Gomes, Alexandre; Lino, Sara; Grau-Pujol, Berta; Magalhães, Sara; Ricoca Peixoto, Vasco; Roque, CarlaAn outbreak of hepatitis A is ongoing in Portugal, with 71 confirmed cases from 7 October 2023 to 24 April 2024. Most cases are male, aged 18-44 years, with many identifying as men who have sex with men (MSM) and reported as suspected sexual transmission. Phylogenetic analysis identified the subgenotype IA, VRD 521-2016 strain, last observed in an MSM-associated multi-country outbreak in 2016 to 2018. We wish t...
Securing wider EU commitment to the elimination of hepatitis C virus
Wedemeyer, Heiner; Tergast, Tammo L.; Lazarus, Jeffrey V.; Razavi, Homie; Bakoyannis, Kostas; Baptista-Leite, Ricardo; Bartoli, Marco; Bruggmann, PhilipIn 2016, the Hepatitis B and C Public Policy Association (HepBCPPA), gathered all the main stakeholders in the field of hepatitis C virus (HCV) to launch the now landmark HCV Elimination Manifesto, calling for the elimination of HCV in the EU by 2030. Since then, many European countries have made progress towards HCV elimination. Multiple programmes—from the municipality level to the EU level—were launched, res...
Phylogeography of hepatitis B virus : the role of Portugal in the early dissemi...
Marcelino, Rute; Ezeonwumelu, Ifeanyi Jude; Janeiro, André; Mimoso, Paula; Matos, Sónia; Briz, Veronica; Pimentel, Victor; Pingarilho, MartaIn Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients followed in Lisbon. HBV genotype A was the most prevalent (n = 54, 41.5%), followed by D (n = 44, 33.8%), and E (...
Transmural remission improves clinical outcomes up to 5 years in Crohn's disease
Fernandes, Samuel Raimundo; Serrazina, Juliana; Botto, Inês Ayala; Leal, Tiago; Guimarães, Andreia; Garcia, Joana Lemos; Rosa, Isadora; Prata, RitaIntroductionEvidence supporting transmural remission (TR) as a long-term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic (IER) or radiologic remission (IRR) may also be acceptable options in the long-term. MethodsMulticenter retrospective study including 404 CD patients evaluated by magnetic resonance enterography and colonosco...
Consumption of Alcohol and Drugs in the School Population of Sao Tome and Principe
De Santiago, Isabel; Ribeiro, Ruy; Nicolau, Leonor Bacelar; Marinho, Rui Tato; Pereira-Miguel, JoséIntroduction: In Sao Tome and Principe there are no studies on alcohol and drug use among students, who could be potential allies in preventive interventions. The objectives of the present study are 1) to determine the frequency of alcohol and drug consumption in the school population, and 2) to identify the main characteristics associated with this behaviour.Material and Methods: We applied a biographical, dem...
Prevention Harmful Consumption of Alcohol and Drugs in Sao Tome and Principe Th...
De Santiago, Isabel; Nicolau, Leonor Bacelar; Marinho, Rui Tato; Pereira-Miguel, JoséIntroduction: Sao Tome and Principe is an African low-and-middle-income country, where extreme poverty causes major health inequalities. No systematic research has been done on the consumption of alcohol and drugs in Sao Tome and Principe, and only overall statistics are available based on the importation of alcoholic drinks and their distribution among the population. There are also no studies on consumption o...
Impact of Disruptive Innovative Medicines on the Health System Hepatitis C: “Pe...
Marinho, Rui TatoE depois da hepatite nÃo-A, não-B (NANB) veio o vírus da hepatite C. Corria o ano de 1989. Dois eventos marcariam em 1989 o futuro, agora presente da Humanidade: a queda do muro de Berlim e a agitação na Praça de Tiananmen. O mundo médico e a virologia assistiam também ao início da queda de um vírus. O mundo mudou com a publicação de cinco páginas na revista Science1,2 em que se relata a identificação do vírus ...
Epidemic history of hepatitis C virus genotypes and subtypes in Portugal
Palladino, Claudia; Ezeonwumelu, Ifeanyi Jude; Marcelino, Rute; Briz, Verónica; Moranguinho, Inês; Serejo, Fátima; Velosa, José FernandoAny successful strategy to prevent and control HCV infection requires an understanding of the epidemic behaviour among the different genotypes. Here, we performed the first characterization of the epidemic history and transmission dynamics of HCV subtypes in Portugal. Direct sequencing of NS5B was performed on 230 direct-acting antiviral drugs (DAA)-treatment naïve patients in Lisbon. Phylogenetic analysis was ...
Thank You, Reviewers of Acta Médica Portuguesa
Silva, José Manuel; Marinho, Rui TatoN/A.; N/a