3 documents found, page 1 of 1
The nuclear levels of thioredoxin reductase 1, gamma-H2AX, and yap are modulate...
Marques, Rita; Ginete, Catarina; Veiga, Luisa; Brito, Miguel; Soares, Helena; Carmona, Bruno; Paiva, Mariana; Nolasco, Sofia; Marinho, Susana H.Diabetes is a condition characterized by impaired regulation of blood glucose levels, leading to various complications such as hypertension, cardiovascular disease, and retinopathy. Diabetic retinopathy (DR), caused by a disrupted retinal blood barrier, is associated with oxidative stress resulting from dysregulated glucose levels in the retina. The primary cilium, an organelle involved in energy balance and gl...
Os cílios primários regulam os níveis de tiorredoxina redutase 1 e de yH2AX em ...
Marques, Rira; Paiva, Mariana; Ginete, Catarina; Nolasco, Sofia; Marinho, Susana H.; Veiga, Luisa; Brito, Miguel; Soares, Helena; Carmona, BrunoA diabetes caracteriza-se por uma anormal capacidade de controlar o nível de glucose na corrente sanguínea, podendo levar a outras complicações, tais como hipertensão, doenças cardiovasculares, e retinopatia. A desregulação dos níveis de glucose na retina tem demonstrado aumentar os níveis de peróxido de hidrogénio, conduzindo a uma rutura na barreira sanguínea da retina, uma das causas de retinopatia diabética...
From cilia to cancer: the two splicing variants of the human TBCCD1 gene
Carmona, Bruno; Justino, Gonçalo; Matos, Catarina; Pádua, Mário; Nolasco, Sofia; Marinho, Susana H.; Soares, HelenaAlmost all human genes that contain multiple exons undergo alternative splicing. Therefore, a single gene can originate multiple mRNA isoforms which causes a dramatic increase in the variability of the expected proteome. Noteworthy, phenotypic variability and disease susceptibility in human populations are related to alternative splicing. Published work from our group identified a new human centrosomal protein,...