51 documents found, page 1 of 6

Uncovering the mechanisms of protection during mycobacterium tuberculosis infec...

Tuberculosis (TB) is one of the most devastating infectious diseases affecting humankind, having caused 1.25 million deaths in 2023. The identification of effective protective mechanisms in TB could critically contribute to the urgent need of new therapies to stop TB. It is known that genetically related Mycobacterium tuberculosis (Mtb) isolates shape the immune response and disease outcomes. Using the natural ...

The genetic diversity of Mycobacterium tuberculosis and its contribution to tub...

Introduction: Tuberculosis remains a global problem, with over 10.6 million new cases and more than 1.3 million fatalities each year. Despite a steady decline in these numbers over the past decades, the COVID-19 pandemic has reversed this downward trend. It is globally accepted that the fight against tuberculosis will require better means of prevention, diagnosis, and therapy. Fundamental research in these area...

The how and the when of semantic illusions in native and non-native languages

The nature and processing of semantic illusions (SI; when speakers fail to notice an anomalous word in a sentence that is contextually perfectly aligned with world knowledge) have been largely studied during first language comprehension. Although this issue is not free of controversy, findings sustain The Node Structure Theory, according to which SI is a phonological and/or semantic priming effect which occurs ...

Association between culture and the preference for, and perceptions of, 11 rout...

Medicines can be taken by various routes of administration. These can impact the effects and perceptions of medicines. The literature about individuals' preferences for and perceptions of the different routes of administration is sparse, but indicates a potential influence of culture. Our aim was to determine: (i) any association between one's culture and one's preferred route of medicine administration and (ii...

Downstream processing of amorphous and co-amorphous Olanzapine powder blends

The work evaluates the stability of amorphous and co-amorphous olanzapine (OLZ) in tablets manufactured by direct compression. The flowability and the compressibility of amorphous and co-amorphous OLZ with saccharin (SAC) and the properties of the tablets obtained were measured and compared to those of tablets made with crystalline OLZ. The flowability of the amorphous and mostly of the co-amorphous OLZ powders...

Polymers enhancing bioavailability in drug delivery

Sulfonic acid derivatives in the production of stable co-amorphous systems for ...

"Co-amorphization is a promising approach to stabilize drugs in the amorphous form. Olanzapine, a poorly water-soluble drug was used in this study. Sulfonic acids (saccharin, cyclamic acid and acesulfame), free and in salt forms, were used as co-formers and compared with carboxylic acids commonly used in the preparation of co-amorphous systems. Several manufacturing techniques were tested, and the co-amorphous ...

In-situ co-amorphization of olanzapine in pellets

Amorphous and co-amorphous Olanzapine stability in formulations intended for we...

The preparation of amorphous and co-amorphous systems (CAMs) effectively addresses the solubility and bioavailability issues of poorly water-soluble chemical entities. However, stress conditions imposed during common pharmaceutical processing (e.g., tableting) may cause the recrystallization of the systems, warranting close stability monitoring throughout production. This work aimed at assessing the water and h...

In situ co-amorphization of Olanzapine in the matrix and on the coat of pellets

In situ amorphization is a promising approach, considered in the present work, to enhance the solubility and dissolution rate of olanzapine, while minimizing the exposure of the amorphous material to the stress conditions applied during conventional processing. The production of pellets by extrusion/spheronization and the coating of inert beads were investigated as novel methods to promote the co-amorphization ...