3 documents found, page 1 of 1
Pure Red Cell Aplasia in Follicular Lymphoma with Bone Marrow Involvement and I...
Maia Moço, Leonardo; Ramos, Inês; Brás, Gil; Mariz, José MárioPure red cell aplasia is a rare bone marrow failure syndrome that is often overlooked, as it is potentially associated with other more common diseases. This report describes a 79-year-old man who was referred due to red cell transfusion-dependent anemia, severe reticulocytopenia, and generalized lymphadenopathies. An excisional lymph node biopsy suggested a diagnosis of follicular lymphoma. Trephine biopsy iden...
Chimeric Antigen Receptor T‐Cell Therapy: Potentially Nephrotoxic?
Alferes, Daniela; Coelho, Inês; Ferreira, Hugo; Chuva, Teresa; Paiva, Ana; Chacim, Sérgio; Mariz, José Mário; Maximino Costa, JoséIntroduction: Chimeric antigen receptor (CAR) T‐cell therapy is an effective new treatment for hematologic malignan‐ cies. In this study, we aimed to characterize the acute kidney injury (AKI) and electrolyte disorders among adults with refractory and relapsed haematological malignancies treated with CAR‐T therapy and explore clinical outcomes. Methods: A retrospective, observational study was performed. Adult ...
Management of ibrutinib treatment in patients with B-cell malignancies: clinica...
Carda, José Pedro; Santos, Lurdes; Mariz, José Mário; Monteiro, Pedro; Gonçalves, Humberto Miguel; Raposo, João; Silva, Maria Gomes daIbrutinib, a potent inhibitor of the Bruton tyrosine kinase, has revolutionized the treatment of many B-cell malignancies. Ibrutinib has an established favorable toxicity profile with up to 8 years of experience in clinical trials; however, despite ibrutinib's favorable toxicity profile, dose reductions and treatment discontinuations are becoming more evident in clinical practice, particularly in the setting of...