7 documents found, page 1 of 1
A role for gene-environment interactions in Autism Spectrum Disorder is suggest...
Santos, J.X.; Marques, A.R.; Rasga, C.; Asif, M.; Vilela, J.; Martiniano, H.; Oliveira, G.; Nunes, A.; Vicente, A.M.Objective: Identify potentially pathogenic CNVs and SNVs targeting genes involved in regulation of toxins exposure, namely in detoxification processes and physiological permeability barriers (blood-brain barrier and placenta), in individuals with ASD.
Adapting the early life exposure assessment tool (ELEAT) to Portugal: a pilot s...
Rasga, C.; Santos, J.; Lopes, A.L.; Marques, A.R.; Vilela, J.; Asif, M.; Walker, C.K.; Schmidt, R.J.; Vicente, A.M.The objective was to pilot a Portuguese version of the Early Life Exposure Assessment Tool (ELEAT) for the assessment of the role of environmental exposures in a population of Portuguese children with ASD.
An integrative system biology approach for dissecting Autism Spectrum Disorder
Asif, M.; Rasga, C.; Martiniano, H.; Santos, J.X.; Marques, A.R.; Couto, F.M .; Vicente, A.M.Autism Spectrum Disorder (ASD) is characterized by a wide spectrum of behavioral presentation. Many genetic factors are implicated in ASD, however their role in the heterogeneous ASD phenotype remains elusive. Using data mining-based integrative approaches, we seek to identify patterns of association between ASD phenotypic subgroups and altered biological processes inferred from CNVs targeting brain genes.
Regulatory RNA genes are targeted by Copy Number Variation in Autism Spectrum D...
Marques, A.R.; Martiniano, H.; Santos, J.X.; Vilela, J.; Asif, M.; Oliveira, G.; Romão, L.; Vicente, A.M.Autism Spectrum Disorder (ASD) is a highly heterogeneous neurodevelopmental disorder with an unclear etiology. Genetic factors are estimated to account for 50 to 80% of the familial ASD risk, but most of the genetic determinants are still not known and a role for epigenetic factors is likely. The involvement of noncoding RNAs in ASD is, so far, insufficiently explored. MicroRNA (miRNA) and long noncoding RNA (l...
CNVs targeting genes that regulate exposure to toxicants in Autism Spectrum Dis...
Santos, J.X.; Rasga, C.; Asif, M.; Marques, A.R.; Vicente, A.M.Objective: Our overall goal is to identify genes involved in detoxification and regulation of barrier permeability processes that can mediate the effect of exposure to toxicants in individuals with ASD. For this purpose, we screened large ASD and control datasets for CNVs targeting selected detoxification and barrier permeability genes.
Dietary restraint adaptation and validation of the flexible and rigid control o...
Poinhos, Rui; Rowcliffe, P.; Marques, A.R.; Viana, Victor; Oliveira, Bruno; Correia, Flora
Adaptação e validação das sub-escalas de controlo flexível e rígido do comporta...
Poínhos, Rui; Rowcliffe, P.; Marques, A.R.; Viana, Victor; Oliveira, Bruno; Correia, Flora[abstract]