9 documents found, page 1 of 1

Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0...

Background: Conventional oral levodopa therapy for the treatment of Parkinson's disease can be associated with variations in plasma concentrations. Levodopa infusion strategies might provide more consistent drug delivery and fewer motor fluctuations. We aimed to assess the safety and efficacy of a continuous 24 h/day subcutaneous infusion of ND0612 (a levodopa-carbidopa solution) compared with oral immediate-re...

Neonatal lupus erythematosus: A narrative review

Introduction: Neonatal lupus erythematosus (NLE) is characterized by the transplacental passage of maternal antibodies, mainly anti-Sjogren’s syndrome A/Ro (anti-SSA/Ro) and anti-Sjogren’s syndrome B/La (anti-SSB/La), which bind to the developing fetal tissues. Seropositive mothers may have a diagnosed disease, such as Sjögren’s syndrome, systemic lupus erythematosus, or undifferentiated connective tissue disea...

Qual o papel da Aspirina na prevenção primária do Carcinoma Colorretal em indiv...

Introdução: O Carcinoma Colorretal (CCR) é a 2ªcausa de mortalidade por neoplasia nos países desenvolvidos. A prevenção primária assenta em mudanças de estilo de vida, estando em investigação a “quimioprevenção”. Alguns estudos têm demonstrado benefício da Aspirina (AAS) na prevenção do CCR.Objetivo: Determinar a evidência do efeito da AAS na incidência e mortalidade por CCR, em indivíduos adultos de médio risc...

TACQual study: assessment and improvement of the requests of lumbar spine CT scans

Aim: To characterize the main reasons for requesting lumbar spine computed tomography (CT) scans at primary care units wi-thin a Local Health Unit (ULS), and to intervene in order to improve the quality of such requests. Type of study: Quasi-experimental, pre- post assessment. Local: Six Functional Units (UF) of ULS. Population: Forty-nine family physicians. Methods: All the lumbar spine CT scans performed betw...

Headache and pregnancy: when the family doctor makes a difference

Background: Headache is a common symptom encountered in primary health care. However, it may have features that suggest serious causes. The family doctor should be aware of this risk when faced with a patient with nonspecific symptom. The core competencies of family medicine should allow the doctor to manage uncertainty and to acknowledge various possibilities when faced with a pregnant patient with headache. C...

Psoriasis and cardiovascular risk factors: observational study in an urban popu...

Objectives: Several studies have demonstrated the association between psoriasis and diabetes mellitus, arterial hypertension, dyslipidemia, smoking and obesity. This paper aims to determine if there is an association among psoriasis and cardiovascular risk factors (CVRF) in an urban population of the north of Portugal. Type of study: Observational, cross-sectional study. Local: Healthcare units of the authors. ...

Pemphigoid gestationis: a case report

Case description: Pemphigoid gestationis is a rare autoimmune bullous disease occurring in pregnant women. The disease presents in the second or third trimester of pregnancy or during the postpartum period. A 31 year-old woman, G2P1, at 18 weeks and two days of gestation, presented at an urgent consultation with generalized pruritus. She was treated initially with a first generation oral anti-histaminic without...

Uncomplicated urinary tract infection in women: wait and see or treat?

Caesarean Birth vs. Vaginal Delivery: Effects upon Maternal Satisfaction, Mater...

In order to test the hypothesis that caesarean birth has negative consequences upon newly mothers’ satisfaction and perceptions, women delivering by caesarean birth (WCB) were compared with women delivering by vaginal birth (WVB). Subjects: 180 newly mothers; 93 WCB and 87 WVB. Instruments: A Socio-Demographic Questionnaire developed for this research, the Childbirth Perceptions Questionnaire and the Mother and...