2 documents found, page 1 of 1
P–042 Impact of semen parameters, sperm DNA fragmentation and sperm aneuploidy ...
Maia, M; Almeida, C; Cunha, M; Gonçalves, A; Soares, SS; Severo, M; Marques, CJ; Barros, AMD; Doria, S; Sousa, MStudy question. Should sperm aneuploidies and sperm DNA fragmentation (sDNAfrag) be included as valid tests in the routine investigation of male infertility? Summary answer. Sperm DNA fragmentation was associated with male age, oligozoospermia (OZ), oligoteratozoospermia (OT), astenoteratozoospermia (AT) and oligoastenoteratozoospermia (OAT). Sperm aneuploidies were associated with OT and OAT. What is known alr...
Profiling DNA methylation based on next-generation sequencing approaches: New i...
Barros-Silva. D; Marques, CJ; Henrique, R; Jerónimo, CDNA methylation is an epigenetic modification that plays a pivotal role in regulating gene expression and, consequently, influences a wide variety of biological processes and diseases. The advances in next-generation sequencing technologies allow for genome-wide profiling of methyl marks both at a single-nucleotide and at a single-cell resolution. These profiling approaches vary in many aspects, such as DNA inp...