7 documents found, page 1 of 1
The characterization and cytotoxic evaluation of chondrosia reniformis collagen...
Rocha, Miguel S.; Marques, Catarina F.; Carvalho, Ana C.; Martins, Eva; Ereskovsky, Alexander; Reis, Rui L.; Silva, Tiago H.Chondrosia reniformis is a collagen-rich marine sponge that is considered a sustainable and viable option for producing an alternative to mammalian-origin collagens. However, there is a lack of knowledge regarding the properties of collagen isolated from different sponge parts, namely the outer region, or cortex, (ectosome) and the inner region (choanosome), and how it affects the development of biomaterials. I...
Marine gelatin-methacryloyl-based hydrogels as cell templates for cartilage tis...
Machado, Inês; Marques, Catarina F.; Martins, Eva; Alves, Ana L.; Reis, Rui L.; Silva, Tiago H.Marine-origin gelatin has been increasingly used as a safe alternative to bovine and porcine ones due to their structural similarity, avoiding the health-related problems and sociocultural concerns associated with using mammalian-origin materials. Another benefit of marine-origin gelatin is that it can be produced from fish processing-products enabling high production at low cost. Recent studies have demonstrat...
Marine gelatin-methacryloyl-based hydrogels as cell templates for cartilage tis...
Machado, Inês; Marques, Catarina F.; Martins, Eva; Alves, Ana L.; Reis, R. L.; Silva, Tiago H.Marine-origin gelatin has been increasingly used as a safe alternative to bovine and porcine ones due to their structural similarity, avoiding the health-related problems and sociocultural concerns associated with using mammalian-origin materials. Another benefit of marine-origin gelatin is that it can be produced from fish processing-products enabling high production at low cost. Recent studies have demonstrat...
Engineering 3D printed bioactive composite scaffolds based on the combination o...
Backes, Eduardo H.; Fernandes, Emanuel Mouta; Diogo, Gabriela S.; Marques, Catarina F.; Silva, Tiago H.; Costa, Lidiane C.; Passador, Fabio R.In this study, polylactic acid (PLA) filled with hydroxyapatite (HA) or beta-tricalcium phosphate (TCP) in 5 wt% and 10 wt% of concentration were produced employing twin-screw extrusion followed by fused filament fabrication in two different architectures, varying the orientation of fibers of adjacent layers. The extruded 3D filaments presented suitable rheological and thermal properties to manufacture of 3D sc...
Scaffolding strategies for tissue engineering and regenerative medicine applica...
Pina, Sandra Cristina Almeida; Ribeiro, Viviana Pinto; Marques, Catarina F.; Maia, F. Raquel; Silva, Tiago H.; Reis, R. L.; Oliveira, Joaquim M.During the past two decades, tissue engineering and the regenerative medicine field have invested in the regeneration and reconstruction of pathologically altered tissues, such as cartilage, bone, skin, heart valves, nerves and tendons, and many others. The 3D structured scaffolds and hydrogels alone or combined with bioactive molecules or genes and cells are able to guide the development of functional engineer...
Insights on the properties of levofloxacin-adsorbed Sr- and Mg-doped calcium ph...
Marques, Catarina F.; Matos, Ana C.; Ribeiro, Isabel A. C.; Goncalves, Lidia M.; Bettencourt, Ana; Ferreira, Jose M. F.Several types of biodegradable materials have been investigated for the treatment of osteomyelitis. Calcium phosphate (CaP) ceramics are among the most performing materials due to their resemblance to human hard tissues in terms of mineralogical composition, and proven ability to adsorb and deliver a number of drugs. This research work was intended to study the suitability of modified CaP powders loaded with a ...
Novel doped calcium phosphate-PMMA bone cement composites as levofloxacin deliv...
Matos, Ana C.; Marques, Catarina F.; Pinto, Rosana V.; Ribeiro, Isabel A. C.; Goncalves, Ldia M.; Vaz, Mario A.; Ferreira, J. M. F.; Almeida, Antonio J.Antibiotic-loaded acrylic bone cements (ALABCs) are well-established and cost-effective materials to control the occurrence of bone and joint infections. However, the inexistence of alternative antibiotics other than those already commercially available and the poor ability to bind to bone tissue hampering its biological function are still major drawbacks of ALABCs clinical application. The concept of this rese...