10 documents found, page 1 of 1
Biosurfactants: Properties and Applications in Drug Delivery, Biotechnology and...
Bjerk, Thiago R; Severino, Patricia; Jain, Sona; Marques, Conrado; Silva, Amélia M.; Pashirova, Tatiana; Souto, Eliana B.Surfactants are amphiphilic compounds having hydrophilic and hydrophobic moieties in their structure. They can be of synthetic or of microbial origin, obtained respectively from chemical synthesis or from microorganisms' activity. A new generation of ecofriendly surfactant molecules or biobased surfactants is increasingly growing, attributed to their versatility of applications. Surfactants can be used as drug ...
Biosurfactants: properties and applications in drug delivery, biotechnology and...
Bjerk, Thiago R.; Severino, Patricia; Jain, Sona; Marques, Conrado; Silva, Amélia M.; Pashirova, Tatiana; Souto, Eliana B.Surfactants are amphiphilic compounds having hydrophilic and hydrophobic moieties in their structure. They can be of synthetic or of microbial origin, obtained respectively from chemical synthesis or from microorganisms activity. A new generation of ecofriendly surfactant molecules or biobased surfactants is increasingly growing, attributed to their versatility of applications. Surfactants can be used as drug d...
(+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant A...
Souto, Eliana B.; Zielińska, Aleksandra; Souto, Selma B; Durazzo, Alessandra; Lucarini, Massimo; Santini, Antonello; Atanasov, Atanas G.In this work, we developed a solid lipid nanoparticle (SLN) formulation with (+)-limonene 1,2-epoxide and glycerol monostearate (Lim-SLNs), stabilized with Poloxamer® 188 in aqueous dispersion to modify the release profile of the loaded monoterpene derivative. We also evaluated the role of SLNs in lipid peroxidation and cytotoxicity in a spontaneously transformed aneuploid immortal keratinocyte cell line from a...
Perillaldehyde 1,2-epoxide Loaded SLN-Tailored mAb: Production, Physicochemical...
Souto, Eliana B.; Souto, Selma B.; Zielińska, Aleksandra; Durazzo, Alessandra; Lucarini, Massimo; Santini, Antonello; Horbańczuk, Olaf K.We have developed a new cationic solid lipid nanoparticle (SLN) formulation, composed of Compritol ATO 888, poloxamer 188 and cetyltrimethylammonium bromide (CTAB), to load perillaldehyde 1,2-epoxide, and surface-tailored with a monoclonal antibody for site-specific targeting of human epithelial growth receptor 2 (HER2). Perillaldehyde 1,2-epoxide-loaded cationic SLN (cPa-SLN), with a mean particle size (z-Ave)...
Liquid crystalline drug delivery systems
Nalone, Luciana; Marques, Conrado; Costa, Salvana; Souto, Eliana B.; Severino, PatríciaLiquid crystals (LCs) were discovered in 1888 by Austrian botanist Friedrich Reinitzer (1888). The crystalline liquid system combines the properties of the solid and liquid states simultaneously, thus presenting a mesomorphic state. It can be defined as a positively disordered solid or an orientationally ordered liquid, thus combining the optical and electrical anisotropy of a solid with the mobility and fluidi...
(+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant A...
Souto, Eliana B.; Zielinska, Aleksandra; Souto, Selma B.; Durazzo, Alessandra; Lucarini, Massimo; Santini, Antonello; Silva, Amélia M.In this work, we developed a solid lipid nanoparticle (SLN) formulation with (+)-limonene 1,2-epoxide and glycerol monostearate (Lim-SLNs), stabilized with Poloxamer® 188 in aqueous dispersion to modify the release profile of the loaded monoterpene derivative. We also evaluated the role of SLNs in lipid peroxidation and cytotoxicity in a spontaneously transformed aneuploid immortal keratinocyte cell line from a...
Croton argyrophyllus Kunth essential oil-loaded solid lipid nanoparticles: eval...
Souto, Eliana B.; Severino, Patricia; Marques, Conrado; Andrade, Luciana N.; Durazzo, Alessandra; Lucarini, Massimo; Atanasov, Atanas G.The essential oil from Croton argyrophyllus Kunth is known for its antiproliferative, anti-inflammatory, antinociceptive, and anticancer activities, and is recognized as a source of phytochemicals for potential use in pharmaceutic and food sectors. Solid lipid nanoparticles (SLN) have been produced to load Croton argyrophyllus (CA) Kunth essential oil (CAEO) and its antioxidant properties evaluated in vitro as ...
Perillaldehyde 1,2-epoxide loaded SLN-tailored mAb: production, physicochemical...
Souto, Eliana B.; Souto, Selma B.; Zielinska, Aleksandra; Durazzo, Alessandra; Lucarini, Massimo; Santini, Antonello; Horbánkczuk, Olaf K.We have developed a new cationic solid lipid nanoparticle (SLN) formulation, composed of Compritol ATO 888, poloxamer 188 and cetyltrimethylammonium bromide (CTAB), to load perillaldehyde 1,2-epoxide, and surface-tailored with a monoclonal antibody for site-specific targeting of human epithelial growth receptor 2 (HER2). Perillaldehyde 1,2-epoxide-loaded cationic SLN (cPa-SLN), with a mean particle size (z-Ave)...
In vitro characterization, modelling, and antioxidant properties of Polyphenon-...
Souto, Eliana B.; da Ana, Raquel; Souto, Selma B.; Zielinska, Aleksandra; Marques, Conrado; Andrade, Luciana N.; Horbanczuk, Olaf K.Eudragit S100-coated chitosan microspheres (S100Ch) are proposed as a new oral delivery system for green tea polyphenon-60 (PP60). PP60 is a mixture of polyphenolic compounds, known for its active role in decreasing oxidative stress and metabolic risk factors involved in diabetes and in other chronic diseases. Chitosan-PP60 microspheres prepared by an emulsion cross-linking method were coated with Eudragit S100...
Praziquantel-loaded solid lipid nanoparticles: Production, physicochemical char...
Andrade, Luciana Nalone; Marques, Conrado; Barbosa, Thallysson; Santos, Rafael; Chaud, Marco Vinícius; Ferreira da Silva, ClassiusPraziquantel (PZQ) is an anthelmintic drug, being the first choice for the treatment of schistosomiasis. Its high hydrophobic character and its low water solubility are the main limitations to the development of liquid formulations for the oral administration of the drug. The aim of this work was to develop Solid Lipid Nanoparticles (SLN) for the loading of PZQ for the treatment of S. mansoni infections. PZQ-SL...