2 documents found, page 1 of 1
Recommendations for the implementation of a national lung cancer screening prog...
Fernandes, MGO; Dias, M; Santos, R; Ravara, S; Fernandes, P; Firmino-Machado, J; Antunes, JP; Fernandes, O; Madureira, A; Hespanhol, V; Rodrigues, CLung cancer (LC) is a leading cause of cancer-related mortality worldwide. Lung Cancer Screening (LCS) programs that use low-dose computed tomography (LDCT) have been shown to reduce LC mortality by up to 25 % and are considered cost-effective. The European Health Union has encouraged its Member States to explore the feasibility of LCS implementation in their respective countries. The task force conducted a com...
Targeted gene next-generation sequencing panel in patients with advanced lung a...
Fernandes, MGO; Jacob, M; Martins, N; Moura, CS; Guimarães, S; Reis, J; Justino, A; Pina, MJ; Cirnes, L; Sousa, C; Pinto, J; Marques, JA; Machado, JCIdentification of targetable molecular changes is essential for selecting appropriate treatment in patients with advanced lung adenocarcinoma. Methods: In this study, a Sanger sequencing plus Fluorescence In Situ Hybridization (FISH) sequential approach was compared with a Next-Generation Sequencing (NGS)-based approach for the detection of actionable genomic mutations in an experimental cohort (EC) of 117 pati...