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Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment
Coimbra, Judite R. M.; Marques, Daniela F. F.; Baptista, Salete J.; Pereira, Cláudia Fragão; Moreira, Paula I.; Dinis, Teresa C. P.; Santos, Armanda E.Alzheimer's disease (AD) is a severe neurodegenerative disorder and the most common type of dementia in the elderly. The clinical symptoms of AD include a progressive loss of memory and impairment of cognitive functions interfering with daily life activities. The main neuropathological features consist in extracellular amyloid-β (Aβ) plaque deposition and intracellular Neurofibrillary tangles (NFTs) of hyperpho...
Date: 2018
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Origin: Estudo Geral - Universidade de Coimbra