98 documents found, page 1 of 10
Ausência do pretenso pai: qual a melhor alternativa numa investigação de patern...
Dario, Ana Rita; Marques, Fernanda; Carvalho, Mónica; Amorim, António; Dourado, Catarina G.A maioria das perícias de investigação de parentesco biológico, realizadas pelo Serviço de Genética e Biologia Forense (SGBF), são requisitadas por ordem do Tribunal. A colheita de material biológico é realizada aos intervenientes que, habitualmente, consiste num trio constituído por pretenso pai, mãe e filho/a. No entanto, poderão existir alterações quanto ao número e tipo de intervenientes. Em situações em qu...
Teaching and learning clinical reasoning in nursing education: A student traini...
Leal, Paula; Poeira, Ana; Mendes, Diana Arvelos; Batalha, Nara; Franco, Hugo; Nunes, Lucília; Marques, Fernanda; Paden, Ljubisa; Stefaniak, MalgorzataClinical reasoning is an essential component of nursing. It has emerged as a concept that integrates the core competencies of quality and safety education for nurses. In cooperation with five European partners, Instituto Politécnico de Setúbal (IPS) realized the “Clinical Reasoning in Nursing and Midwifery Education and Practice” project as part of the Erasmus+ project. As a partner, our team designed a multipl...
Image-guided nanodelivery of Pt(IV) prodrugs to GRP-receptor positive tumors
Silva, Francisco; Mendes, Carolina; D'Onofrio, Alice; Campello, Maria Paula Cabral; Marques, Fernanda; Pinheiro, Teresa; Gonçalves, KyleOver the last decades, gold nanoparticles (AuNPs) have proven to be remarkable tools for drug delivery and theranostic applications in cancer treatment. On the other hand, Pt(IV) prodrugs have been employed as an interesting alternative to the more common Pt(II) complexes, such as cisplatin, for cancer chemotherapy. Searching to design an image-guided nanocarrier to deliver selectively Pt(IV) prodrugs to tumors...
Learning the biochemical basis of axonal guidance: using Caenorhabditis elegans...
Castro, Andreia Cristiana Teixeira; Sousa, João Carlos; Vieira, Cármen Maria Leal; Pereira-Sousa, Joana; Vilasboas-Campos, Daniela; Marques, FernandaAim: Experimental models are a powerful aid in visualizing molecular phenomena. This work reports how the worm <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) can be effectively explored for students to learn how molecular cues dramatically condition axonal guidance and define nervous system structure and behavior at the organism level. Summary of work: A loosely oriented observational activity preceded detai...
Antitumoral and antimicrobial activities of block copolymer micelles containing...
Sousa, Andreia; Santos, Joana F.; Silva, Francisco; Sousa, Sílvia A.; Leitão, Jorge H.; Matos, António P.; Pinheiro, Teresa; Silva, Rafaela A. L.Gold(III) bisdithiolate complexes have been reported as potential antimicrobial and antitumoral agents. The complex [Au(cdc)2]− (cdc=cyanodithioimido carbonate) displayed antimicrobial and outstanding antitumor activity against the ovarian cancer cells A2780 and A2780cisR, which are sensitive and resistant to cisplatin, respectively. However, poor water solubility may hamper its clinical use. Block copolymer mi...
Profiling microglia in a mouse model of Machado–Joseph disease
Campos, Ana Bela; Silva, Sara Duarte; Fernandes, Bruno; Neves, Sofia Pereira das; Marques, Fernanda; Castro, Andreia Teixeira; Carvalho, Andreia NevesMicroglia have been increasingly implicated in neurodegenerative diseases (NDs), and specific disease associated microglia (DAM) profiles have been defined for several of these NDs. Yet, the microglial profile in Machado–Joseph disease (MJD) remains unexplored. Here, we characterized the profile of microglia in the CMVMJD135 mouse model of MJD. This characterization was performed using primary microglial cultur...
Profiling microglia in a mouse model of Machado-Joseph disease
Campos, Ana Bela; Silva, Sara Carina Duarte; Fernandes, B.; Neves, Sofia Pereira; Marques, Fernanda; Castro, Andreia Cristiana TeixeiraMicroglia have been increasingly implicated in neurodegenerative diseases (NDs), and specific disease associated microglia (DAM) profiles have been defined for several of these NDs. Yet, the microglial profile in Machado–Joseph disease (MJD) remains unexplored. Here, we characterized the profile of microglia in the CMVMJD135 mouse model of MJD. This characterization was performed using primary microglial cultur...
The Role of Biobanks in the Fight against COVID-19 Pandemic: The Portuguese Res...
Abdulghani, Saba; Afonso, Ângela; Castillo, Mireia; Martín-Fernández, Javier; Franco, Inês; Parreira, Bruna; Couto, Ana; Bruges-Armas, JácomeN/a.; N/a.
Satisfação dos clientes da cirurgia de catarata com a consulta pré-operatória d...
Ferreira, Ana; Marques, Fernanda; Príncipe, Fernanda; Mota, Liliana; Cardoso, Manuela; Vieira, RuiIntrodução: O aumento da esperança média de vida da população portuguesa, leva ao aparecimento de cataratas e, consequentemente, à intervenção cirúrgica para a resolução deste problema. Objetivo: identificar a satisfação do cliente com a consulta pré-operatória de enfermagem de cirurgia de catarata em regime de ambulatório. Métodos:: Estudo quantitativo, descritivo e exploratório. A amostra não probabilística p...
Design and anticancer properties of new water-soluble ruthenium–cyclopentadieny...
Morais, Tânia; Marques, Fernanda; Madeira, Paulo J. Amorim; Robalo, M.P.; Garcia, Maria HelenaRuthenium complexes are emerging as one of the most promising classes of complexes for cancer therapy. However, their limited aqueous solubility may be the major limitation to their potential clinical application. In view and to contribute to the progress of this field, eight new water-soluble Ru(II) organometallic complexes of general formula [RuCp(mTPPMS)n(L)] [CF3SO3], where mTPPMS = diphenylphosphane-benzen...