9 documents found, page 1 of 1

Synthesis and in vitro antifungal activity of isoniazid-derived hydrazones agai...

Coccidioidomycosis is a potentially severe infection caused by dimorphic fungi Coccidioides immitis and Coccidioides posadasii . Although guidelines are well established, refractory disease is a matter of concern in the clinical management of coccidioidomycosis. In the present study three isoniazid-derived hydra- zones N 0 -[( E )-1-(4-methoxyphenyl)ethylidene]pyridine-4-carbohydrazide, N 0 -[( E )-1-(4-methylp...

Efeito inibitório de drogas antituberculose frente à Histoplasma capsulatum var...

Synthesis and antifungal activity In vitro of isoniazid derivatives against his...

Histoplasmosis is a severe infection that affects millions of patients worldwide and is endemic in the Americas. Amphotericin B (AMB) and itraconazole are highly effective for the treatment of severe and milder forms of the disease, but AMB is toxic, and the bioavailability of itraconazole is erratic. Therefore, it is important to investigate new classes of drugs for histoplasmosis treatment. In this study, a s...

Antigens of Coccidioides posadasii as an Important Tool for the Immunodiagnosis...

Serologic diagnosis has been presented as a safe alternative for coccidioidomycosis. However, commercial kits based on coccidioidal antibodies available in the USA are considered too expensive for laboratories outside that country. In this study, we describe the preparation of antigens for detection of human coccidioidal antibodies by the immunodiffusion test (ID) and enzyme immunoassay (EIA). Antigens were tes...

Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to...

The aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The m...

Ciprofloxacin shows synergism with classical antifungals against Histoplasma ca...

This study evaluated the in vitro interaction between ciprofloxacin (CIP) and classical antifungals against Histoplasma capsulatum var. capsulatum in mycelial (n = 16) and yeast-like forms (n = 9) and Coccidioides posadasii in mycelial form (n = 16). This research was conducted through broth microdilution and macrodilution, according to Clinical Laboratory Standards Institute. Inocula were prepared to obtain fr...

Synergistic Effect of Antituberculosis Histoplasma capsulatum var. capsulatum D...

This study evaluated in vitro interactions of antituberculosis drugs and triazoles against Histoplasma capsulatum. Nine drug combinations, each including an antituberculosis drug (isoniazid, pyrazinamide, or ethambutol) plus a triazole (itraconazole, fluconazole, or voriconazole), were tested against both growth forms of H. capsulatum. Stronger synergistic interactions were seen in isoniazid or pyrazinamide plu...

Coccidioides posadasii infection in bats, Brazil

Studies have demonstrated that bats (order Chiroptera) are reservoirs for many infectious agents, including protozoa, bacteria, viruses, and fungi (1). Several studies confi rm that bats have a great effect on human health because they can transmit numerous infectious agents and provide a reservoir for emerging pathogens (1,2). The interaction between these animals and pathogenic fungi is well illustrated by th...

Efeito inibitório in vitro de drogas antituberculose, antifúngicas e análogos q...

In the past years, the improvement of mycological diagnosis methods and immunosuppressive diseases have caused a great impact in the incidence of opportunistic and deep mycoses all around the world, which motivated the performance of new antifungal drugs prospective studies. Histoplasmosis is a systemic mycosis caused by the fungus Histoplasma capsulatum var. capsulatum, which may mimic tuberculosis, in healthy...