3 documents found, page 1 of 1
A single-step multicomponent synthesis of a quinoline derivative and the charac...
Pinto, Luciana Matos Alves; Adeoye, Oluwatomide; Thomasi, Sérgio Scherrer; Francisco, Ana Paula; Marques, Helena CabralMulticomponent synthesis are convergent reactions in which three or more starting materials react in a single step to form the product. In the discovery and development of new drugs, multicomponent reactions offer several advantages over traditional synthesis: shorter experiment time, less need for laboratory techniques and scalability. Thus, the objective of this work was to perform the multicomponent synthesi...
Pyromellitic dianhydride crosslinked soluble cyclodextrin polymers: Synthesis, ...
Adeoye, Oluwatomide; Bártolo, Inês; Conceição, Jaime; Bento-Silva, Andreia; Duarte, Noélia; Francisco, Ana Paula; Taveira, Nuno; Marques, Helena CabralWe report the synthesis of water soluble cyclodextrin (CD) polymers prepared by crosslinking pyromellitic dianhydride (PMDA) with two CD derivatives (methyl-β-CD - MβCD and (2-hydroxy)propyl-β-CD - HPβCD) and their evaluation as functional sub-micron sized carriers in the development of antiretroviral drug delivery systems. Using the protease inhibitor lopinavir (LPV) as model drug, LPV loaded CD polymers (pHPβ...
Competências profissionais no âmbito da prevenção e do tratamento do tabagismo ...
Pereira, Anabela; Albuquerque, Carlos; Carrilho, Eunice; Marques, Helena Cabral; Rosas, Manuel; Matos, Margarida Gaspar de; Oliveira, Maria