24 documents found, page 1 of 3
Patient Blood Management – is its application possible in oncology?
Santos, Alexandra; Oliveira, Ana; Raimundo, Ana; Coelho, Andreia; Monteiro, Andreia; Araújo, António; Moreira, António; Nunes, António; Fonseca, CândidaPatient blood management (PBM) is a safe approach aiming to improve a patient’s medical and surgical management in ways that boost and conserve their own blood. Approximately 32% to 60% of oncology patients have iron deficiency – the majority of whom are anaemic – therefore, it is important to discuss strategies to avoid excessive blood usage and the reduction of tumour progression and cancer recurrence. In thi...
Biometrics and quality of life of lymphoma patients: A longitudinal mixed‐model...
Oliveira, Alexandra; Silva, Eliana; Aguiar, Joyce Cristina Santos; Faria, Mónica Brígida; Reis, L. P.; Cardoso, Henrique; Gonçalves, JoaquimKnowledge Engineering has become essential in the fields of Medical and Health Care with emphasis for helping citizens to improve their health and quality of life. This includes individual methods and techniques in health‐related knowledge acquisition and representation and their application in the construction of intelligent systems capable of using the acquired information to improve the patients' health and/...
Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma ...
Afonso, Julieta Alexandra Pereira; Pinto, Tatiana; Sousa, Susana Patrícia Simões; Schmitt, Fernando; Longatto, Adhemar; Pinheiro, CélineIncreased glycolytic activity with accumulation of extracellular lactate is regarded as a hallmark of cancer. In lymphomas, FDG-PET has undeniable diagnostic and prognostic value, corroborating that these tumours are avid for glucose. However, the role of glycolytic metabolism-related molecules in lymphoma is not well known. Here, we aimed to evaluate the clinical and prognostic significance of a panel of glyco...
Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma-...
Afonso, Julieta; Pinto, Tatiana; Simoes-Sousa, Susana; Schmitt, Fernando; Longatto-Filho, Adhemar [UNESP]; Pinheiro, Celine; Marques, HerlanderMade available in DSpace on 2019-10-04T12:14:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-06-01; Northern Portugal Regional Operational Programme (NORTE 2020) through the European Regional Development Fund (FEDER); Northern Portugal Regional Operational Programme (NORTE 2020) through Competitiveness Factors Operational Programme (COMPETE); Foundation for Science and Technology (FCT); FCT; PurposeIn...
T-Cell Large Granular Lymphocyte Leukemia: The Experience of a Single Center
M. Eira, Isabel; I. Correia, Sandra; Ângela, Cristina; Marques, HerlanderBackground: T-cell large granular lymphocyte (LGL) leukemiais a rare lymphoproliferative disease. It frequently involvesthe expansion of CD8+ cells, which may lead to cytopeniasand often correlates with autoimmune disorders. Anotherform is the CD4+ LGL leukemia, which behaves more indolently but may associate with other neoplasia.Material and Methods: Retrospective and descriptive analysis of the 14 patients di...
Identification of miRSNPs associated with the risk of multiple myeloma
Macauda, Angelica; Calvetti, Diego; Maccari, Giuseppe; Hemminki, Kari; Försti, Asta; Goldschmidt, Hartmut; Weinhold, Niels; Houlston, RichardMultiple myeloma (MM) is a malignancy of plasma cells usually infiltrating the bone marrow, associated with the production of a monoclonal immunoglobulin (M protein) which can be detected in the blood and/or urine. Multiple lines of evidence suggest that genetic factors are involved in MM pathogenesis, and several studies have identified single nucleotide polymorphisms (SNPs) associated with the susceptibility ...
Cost-effectiveness Analysis of Rituximab Maintenance Treatment in Patients With...
Carvalho, Susana; Gomes, Marília; Marques, Herlander; Pereira, Catarina; Rubio-Rodríguez, Darío; Rubio-Terrés, Carlos; Sottomayor, CarlosIntroduction: To perform a cost-effectiveness analysis of follicular lymphoma maintenance treatment after first-line induction with rituximab compared to observation in Portugal.Methods: A Markov follicular lymphoma model was developed with four health states: progression free survival on first and second lines, progression and death. The transition probabilities between health states were obtained from the PRI...
A common variant within the HNF1B gene is associated with overall survival of m...
Ríos-Tamayo, Rafael; Lupiañez, Carmen Belén; Campa, Daniele; Hielscher, Thomas; Weinhold, Niels; Martínez-López, Joaquin; Jerez, Andrés; Landi, StefanoDiabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rE...
Methodology for single nucleotide polymorphism selection in promoter regions fo...
Marques, Herlander; Freitas, J.; Medeiros, Rui; Longatto Filho, AdhemarGenetic variability in humans can explain many differences in disease risk factors. Polymorphism-related studies focus mainly on the single nucleotide polymorphisms (SNPs) of coding regions of the genes. SNPs on DNA binding motifs of the promoter region have been less explored. On a recent study of SNPs in patients with non-Hodgkin lymphomas we faced the problem of SNP selection from promoter regions and develo...
Type 2 diabetes-related variants influence the risk of developing multiple myel...
Ríos, Rafael; Lupiañez, Carmen Belén; Campa, Daniele; Martino, Alessandro; Martínez-López, Joaquin; Martínez-Bueno, Manuel; Varkonyi, JuditType 2 diabetes (T2D) has been suggested to be a risk factor for multiple myeloma (MM), but the relationship between the two traits is still not well understood. The aims of this study were to evaluate whether 58 genome-wide-association-studies (GWAS)-identified common variants for T2D influence the risk of developing MM and to determine whether predictive models built with these variants might help to predict ...