2 documents found, page 1 of 1
An intracellular metabolic signature as a potential donor-independent marker of...
Bispo, Daniela S. C.; Jesus, Catarina S. H.; Romek, Katarzyna; Marques, Inês M. C.; Oliveira, Mariana B.; Mano, João F.; Gil, Ana M.This paper describes an untargeted NMR metabolomics study to identify potential intracellular donor-dependent and donor-independent metabolic markers of proliferation and osteogenic differentiation of human adipose mesenchymal stem cells (hAMSCs). The hAMSCs of two donors with distinct proliferating/osteogenic characteristics were fully characterized regarding their polar endometabolome during proliferation and...
Metabolomic applications in stem cell research: a review
Bispo, Daniela S. C.; Jesus, Catarina S. H.; Marques, Inês M. C.; Romek, Katarzyna M.; Oliveira, Mariana B.; Mano, João F.; Gil, Ana M.This review describes the use of metabolomics to study stem cell (SC) characteristics and function, excluding SCs in cancer research, suited to a fully dedicated text. The interest in employing metabolomics in SC research has consistently grown and emphasis is, here, given to developments reported in the past five years. This text informs on the existing methodologies and their complementarity regarding the inf...