6 documents found, page 1 of 1
Liquid biopsy for disease monitoring in non-small cell lung cancer: The link be...
Fernandes, G; Sousa, C; Reis, J; Martins, N; Moura, CS; Guimarães, S; Justino, A; Pina, MJ; Magalhães, A; Queiroga, H; Marques, JA; Machado, JCIntroduction: Cell-free DNA (cfDNA) analysis offers a non-invasive method to identify sensitising and resistance mutations in advanced Non-Small Cell Lung Cancer (NSCLC) patients. Next-generation sequencing (NGS) of circulating free DNA (cfDNA) is a valuable tool for mutations detection and disease' s clonal monitoring. Material and methods: An amplicon-based targeted gene NGS panel was used to analyse 101 plas...
Asthma Management With Breath-Triggered Inhalers: Innovation Through Design
Morais-Almeida, M; Pité, H; Cardoso, J; Costa, R; Robalo Cordeiro, C; Silva, E; Todo-Bom, A; Vicente, C; Marques, JABackground: Asthma affects the lives of hundred million people around the World. Despite notable progresses in disease management, asthma control remains largely insufficient worldwide, influencing patients' wellbeing and quality of life. Poor patient handling of inhaling devices has been identified as a major persistent problem that significantly reduces inhaled drugs' efficacy and is associated with poor adhe...
Tax audits as a path to tax compliance in Portugal
Marques, JA; Pedro António Basto de Sousa; Teixeira, GResponsive regulation has a special role within compliance. It has been implemented by tax authorities through the adoption of regulatory pyramids that cover the general relationship between the tax authorities and taxpayers. Here, the effects of both the Kirchler slippery slope framework and the Braithwaitian compliance pyramid are explored to design an alternative strategy to maximise the likelihood of restit...
Targeted gene next-generation sequencing panel in patients with advanced lung a...
Fernandes, MGO; Jacob, M; Martins, N; Moura, CS; Guimarães, S; Reis, J; Justino, A; Pina, MJ; Cirnes, L; Sousa, C; Pinto, J; Marques, JA; Machado, JCIdentification of targetable molecular changes is essential for selecting appropriate treatment in patients with advanced lung adenocarcinoma. Methods: In this study, a Sanger sequencing plus Fluorescence In Situ Hybridization (FISH) sequential approach was compared with a Next-Generation Sequencing (NGS)-based approach for the detection of actionable genomic mutations in an experimental cohort (EC) of 117 pati...
Síndroma compartimental aguda ou das locas: Conceitos essenciais
Canha, MI; Marques, JAA síndroma compartimental aguda define-se como sendo a falência da circulação intersticial por conflito de espaço. Representa, habitualmente, uma severa complicação das lesões traumáticas, podendo envolver potencialmente qualquer compartimento do organismo. Mais frequente em fraturas de alta energia cinética e em lesões por esmagamento dos membros, é uma verdadeira emergência ortopédica, por forma a conseguir-s...
Anquilose da anca: tratamento cirúrgico
Marques, JA; Judas, FA anquilose da anca pode ser compatível com uma função aceitável, em doentes jovens ativos. Todavia, a imobilidade da anca pode contribuir para a doença articular degenerativa das articulações anexas, como é o caso da coluna lombosagrada, joelho homolateral e anca contralateral.. A conversão da anquilose em artroplastia permite a supressão da dor e a melhoria da qualidade de vida, mau grado as complicações que ...