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Antinociceptive effects of interleukin-4, -10, and -13 on the writhing response...
Vale, Mariana L.; Marques, Jaciara B.; Moreira, Camila A.; Rocha, Francisco Aírton C.; Ferreira, Sérgio H.; Poole, Stephen; Cunha, Fernando Q.The antinociceptive effects of interleukin (IL)-4, -10, and -13 were investigated in two different experimental pain models. Our results showed that pretreatment (30 min) with IL-4 (1–5 ng/animal), IL-10 (0.4–10 ng/animal), or IL-13 (0.4 –2.5 ng/animal) inhibited the writhing response induced by the i.p. administration of acetic acid (53–89%) or zymosan (63–74%) in mice, and the knee joint incapacitation induce...
Date: 2013
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Origin: Oasisbr