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Loss of antiphospholipid antibody positivity decreases the risk of recurrent th...

OBJECTIVE: To establish the predictive value of antiphospholipid antibody (aPL) negativization on recurrent thrombosis in thrombotic antiphospholipid syndrome (APS). METHODS: Retrospective cohort study including all consecutive adult patients with APS followed at Hospital de Santa Maria, Lisbon, Portugal, up to December 2024. At diagnosis, all patients were positive for solid-phase aPL. Then, patients were cate...

Inflammatory Biomarkers in Diabetic Macular Edema

Diabetic retinopathy (DR) is a major complication of both Type 1 and Type 2 diabetes mellitus (T1DM and T2DM). Disease progression can result in visual impairment, primarily due to diabetic macular edema (DME) or proliferative diabetic retinopathy (PDR). Although several ocular treatments are available for DME, a subset of patients fails to respond, reflecting the multifactorial, complex, and systemic nature of...

Worldwide Soundscapes: A Synthesis of Passive Acoustic Monitoring Across Realms

Aim The urgency for remote, reliable and scalable biodiversity monitoring amidst mounting human pressures on ecosystems has sparked worldwide interest in Passive Acoustic Monitoring (PAM), which can track life underwater and on land. However, we lack a unified methodology to report this sampling effort and a comprehensive overview of PAM coverage to gauge its potential as a global research and monitoring tool. ...

Genetic Testing of Patients with Inherited Retinal Diseases in the European Cou...

Introduction: The purpose of this project was to explore the current standards of clinical care genetic testing and counseling for patients with inherited retinal diseases (IRDs) from the perspective of leading experts in selected European countries. Also, to gather opinions on current bottlenecks and future solutions to improve patient care. Methods: On the initiative of the European Vision Institute, a survey...

Effect of blanching, storage and drying conditions on the macro-composition, co...

For food applications, the processing conditions applied to edible insects should present low energy requirements and environmental impact, while also assuring high quality and safety. The main goal of this study was to assess how different blanching, storage and drying conditions influence the quality and safety of Tenebrio molitor larvae. The different operations included blanching treatments (water-immersion...

Double Concentric Hyperautofluorescent Ring in EYS-Associated Retinitis Pigmentosa

Response to "Comment on the Article: Subretinal Bleb of Voretigene Neparvovec"

Mutational Spectrum, Ocular and Olfactory Phenotypes of CNGB1-Related RP-Olfact...

CNGB1 gene mutations are a well-known cause of autosomal recessive retinitis pigmentosa (RP), which was recently associated with olfactory dysfunction. The purpose of this study was to report the molecular spectrum and the ocular and olfactory phenotypes of a multiethnic cohort with CNGB1-associated RP. A cross-sectional case series was conducted at two ophthalmic genetics referral centers. Consecutive patients...

Building a Portuguese Coalition for Biodiversity Genomics

The diverse physiography of the Portuguese land and marine territory, spanning from continental Europe to the Atlantic archipelagos, has made it an important repository of biodiversity throughout the Pleistocene glacial cycles, leading to a remarkable diversity of species and ecosystems. This rich biodiversity is under threat from anthropogenic drivers, such as climate change, invasive species, land use changes...

The European Reference Genome Atlas: piloting a decentralised approach to equit...

ABSTRACT: A global genome database of all of Earth’s species diversity could be a treasure trove of scientific discoveries. However, regardless of the major advances in genome sequencing technologies, only a tiny fraction of species have genomic information available. To contribute to a more complete planetary genomic database, scientists and institutions across the world have united under the Earth BioGenome P...