4 documents found, page 1 of 1
A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line
Silva, Jéssica D.; Marques, Joana; Santos, Inês P.; Carvalho, Ana L. M. Batista de; Martins, Clara B.; Laginha, Raquel; Batista de Carvalho, Luís A. E.A dinuclear Pt(II) complex with putrescine as bridging polyamine ligand ([Pt2Put2(NH3)4]Cl4) was synthesized and assessed as to its potential anticancer activity against a human non-small cell lung cancer line (A549), as well as towards non-cancer cells (BEAS-2B). This effect was evaluated through in vitro cytotoxicity assays (MTT and SRB) coupled to microFTIR and microRaman spectroscopies, the former deliverin...
Evaluation of the Cytotoxic Effect of Pd2Spm against Prostate Cancer through Vi...
Laginha, Raquel C.; Martins, Clara B.; Brandão, Ana L.; Marques, Joana; Marques, M. P.aula M.; Batista de Carvalho, Luís A. E.; Santos, Inês P.Regarding the development of new antineoplastic agents, with a view to assess the selective antitumoral potential which aims at causing irreversible damage to cancer cells while preserving the integrity of their healthy counterparts, it is essential to evaluate the cytotoxic effects in both healthy and malignant human cell lines. In this study, a complex with two Pd(II) centers linked by the biogenic polyamine ...
Antioxidant Potential of Tamarillo Fruits-Chemical and Infrared Spectroscopy An...
Rito, Miguel; Marques, Joana; Costa, Ricardo M. F. da; Correia, Sandra; Lopes, Tércia; Martin, Daniel; Canhoto, Jorge M. P. L.Native to South America, tamarillo (Solanum betaceum Cav.) is a small tree cultivated as a fruit crop in several regions of the world. Known for its sweet and sour taste, tamarillo fruits are very nutritious due to the presence of health-beneficial components such as fiber, vitamins, and antioxidants. Despite its nutritional value, tamarillo remains poorly known in global markets. The present work aims to study...
Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Act...
Vojtek, Martin; Martins, Clara B.; Ramos, Raquel; Duarte, Sara Gomes; Ferreira, Isabel M. P. L. V. O.; Carvalho, Ana L. M. Batista deTriple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10-20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, novel drug entities with improved tolerability and selectivity profiles, as w...