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Factors associated with patient delay in the diagnosis of TB – a study of healt...

Marques, MS; Silva, T; Gomes, A; Pereira, C; Pinto, M; Aguiar, A; Duarte, R


Tuberculosis incidence in foreign-born people residing in European countries in...

Vasiliu, A; Köhler, N; Altpeter, E; Ægisdóttir, TR; Amerali, M; de Oñate, WA; Bakos, Á; D'Amato, S; Cirillo, DM; van Crevel, R; Davidaviciene, E

"Background European-specific policies for tuberculosis (TB) elimination require identification of key populations that benefit from TB screening. Aim We aimed to identify groups of foreign-born individuals residing in European countries that benefit most from targeted TB prevention screening. Methods The Tuberculosis Network European Trials group collected, by cross-sectional survey, numbers of foreign-born TB...


Patients' perspective and lung function correlation:the importance of questionn...

Fonseca, AD; Marques, MS; Conde, S; Oliveira, P; Nogueira, C; Ferreira, D; Adler, D; Windisch, W; Nunes, R; Ribeiro, C

Classical physiological variables used to monitor respiratory function in patients under non-invasive ventilation (NIV), such as FEV1 or FVC, correlate poorly with reported impairment of physical function or overall health status and hence provide an incomplete picture of impaired health. Aim: to investigate the association between the Portuguese S3-non-invasive ventilation (S3-NIV) questionnaire score and obje...


Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhe...

Marques, MS; Costa, AC; Osorio, H; Pinto, ML; Relvas, S; Dinis-Ribeiro, M; Carneiro, F; Leite, M; Figueiredo, C

Helicobacter pylori infects approximately half of the world’s population and is the strongest risk factor for peptic ulcer disease and gastric cancer, representing a major global health concern. H. pylori persistently colonizes the gastric epithelium, where it subverts the highly organized structures that maintain epithelial integrity. Here, a unique strategy used by H. pylori to disrupt the gastric epithelial ...


Afadin downregulation by helicobacter pylori Induces epithelial to mesenchymal ...

Marques, MS; Melo, J; Cavadas, B; Mendes, N; Pereira, L; Carneiro, F; Figueiredo, C; Leite, M

Afadin is a cytoplasmic protein of the adherens junctions, which regulates the formation and stabilization of both the adherens and the tight junctions. Aberrant expression of Afadin has been shown in cancer and its loss has been associated with epithelial-tomesenchymal transition (EMT). EMT is characterized by the change from an epithelial to a mesenchymal phenotype, with modifications on the expression of adh...


Allergic contact dermatitis in children. A multicenter study of the Portuguese ...

Gonçalo, S; Gonçalo, Margarida; Azenha, A; Barros, MA; Sousa-Bastos, A; Brandão, FM; Faria, A; Marques, MS; Pecegueiro, M; Rodrigues, JB; Salgueiro, E

The authors report a study of allergic contact dermatitis in 329 Portuguese children of 14 years or younger. 170 children (64 male and 106 female) reacted to 1 or more allergens. Most of these were in the 11-14 years group. The main allergens were nickel, thimerosal, cobalt, mercury, fragrance-mix and potassium dichromate. Nickel reactivity predominated in females over the whole group, but a greater number of m...


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