Universidade Federal de Juiz de Fora. Instituto de Ci?ncias Biol?gicas. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brasil.; Secretaria Municipal de Sa?de de Juiz de Fora. Departamento de Vigil?ncia Epidemiol?gica e Ambiental. Setor de Zoonoses. Juiz de Fora, MG, Brasil / Universidade Federal de Juiz de Fora. Programa de P?s-Gradua??o em Sa?de Brasileira. Juiz de Fora, MG, Brasi...
Eight coumarin derivatives (2–8) were synthesized from 7-hydroxy-4-phenylcoumarin 1 and were evaluated for their in vitro leishmanicidal activity against promastigote and amastigote forms of Leishmania amazonensis, as well their toxicity in murine macrophages. Compounds 4 and 7 showed the most significant results against promastigote forms of L. amazonensis. They were at least three-fold more active than 1 and ...
Compounds [{Ag(phen)(mu-tu)}(2)](NO3)(2) (1), [{Ag(phen)(mu-tu)}(2)](CF3SO3)(2) (2), [{Ag(bpy)(mu-tu)}(2)](NO3)(2) (3) (where phen = 1,10-phenanthroline; bpy = 2,2'-bipyridine; tu = thiourea) were prepared by reacting the appropriate AgX salt (X- = NO3-, CF3SO3-), the N,N-chelating ligand (phen or bpy) and thiourea in a ca. 1:1:2 M ratio, respectively. The silver(l) complexes were characterized by elemental ana...