7 documents found, page 1 of 1
A novel approach in glioblastoma multiforme drug discovery: perturbation studie...
Oliveira, Luís Carlos; Marques, Maria Paula; Caseiro, Armando José; Rapposelli, Simona; Carvalho, Ana Lúcia Batista de; Fonseca, Ana PaulaDespite impressive advances in drug discovery methods, predicting cellular response to anticancer drugs remains challenging. In glioblastoma multiforme, this fact is even marked as many promising drugs were followed by disappointment. As a result, the aim of this study is to clarify the effects of inhibition of 3-phosphoinositide-dependent protein kinase-1 (PDK1) in glioblastoma multiforme, while exploring how ...
Multi-Organ NMR Metabolomics to Assess In Vivo Overall Metabolic Impact of Cisp...
Carneiro, Tatiana J.; Araújo, Rita; Vojtek, Martin; Gonçalves-Monteiro, Salomé; Diniz, Carmen; Batista de Carvalho, Ana L. M.; Marques, Maria PaulaThis work describes, to our knowledge, the first NMR metabolomics analysis of mice kidney, liver, and breast tissue in response to cisplatin exposure, in search of early metabolic signatures of cisplatin biotoxicity. Balb/c mice were exposed to a single 3.5 mg/kg dose of cisplatin and then euthanized; organs (kidney, liver, breast tissue) were collected at 1, 12, and 48 h. Polar tissue extracts were analyzed by...
Bach, Sonatas BWV 1001, 1003, 1005 – Abordagens Interpretativas na Guitarra
Marques, Maria PaulaThis paper considers the interpretative approaches to Bach’s violin sonatas presented thus far on the guitar and provides an alternative proposal. It includes a systematic presentation of the main characteristics of transcriptions and recordings, and focuses on its interpretative consequences. The analysis I undertook showed some main strategies: addition of notes, modification of rhythmic values, alterations o...
Bioinspired-Metalloporphyrin Magnetic Nanocomposite as a Reusable Catalyst for ...
Dias, Lucas D.; Batista de Carvalho, Ana L. M.; Pinto, Sara M. A.; Aquino, Gilberto L. B.; Calvete, Mário J. F.; Rossi, Liane M.; Marques, Maria PaulaIn the present study, we developed a green epoxidation approach for the synthesis of the diastereomers of (-)-isopulegol benzyl ether epoxide using molecular oxygen as the oxidant and a hybrid manganese(III)-porphyrin magnetic reusable nanocomposite as the catalyst. High activity, selectivity, and stability were obtained, with up to four recycling cycles without the loss of activity and selectivity for epoxide....
Norspermidine and Novel Pd(II) and Pt(II) Polynuclear Complexes of Norspermidin...
Silva, Tânia Magalhães; Andersson, Sara; Sukumaran, Sunil Kumar; Marques, Maria Paula; Persson, Lo; Oredsson, StinaNew strategies are needed for breast cancer treatment and one initial step is to test new chemotherapeutic drugs in breast cancer cell lines, to choose candidates for further studies towards clinical use.
Helianthus tuberosus and polyamine research: Past and recent applications of a ...
Tassoni, Annalisa; Bagni, Nello; Ferri, Maura; Franceschetti, Marina; Khomutov, Alex; Marques, Maria Paula; Fiuza, Sónia M.; Simonian, Alina R.The earliest studies concerning polyamines (PAs) in plants were performed by using in vitro cultured explants of Helianthus tuberosus dormant tuber. This parenchyma tissue was particularly useful due to its susceptibility to several growth substances, including PAs. During tuber dormancy, PA levels are too low to sustain cell division; thus Helianthus represents a natural PA-deficient model. When cultivated in ...
A glycine ruthenium trithiacyclononane complex and its molecular encapsulation ...
Marques, Joana; Santos, Teresa M.; Marques, Maria Paula; Braga, Susana S.The complex Ru([9]aneS(3))(gly)Cl (gly = glycine) was obtained from the reaction of the precursor Ru([9]aneS(3))dmsoCl(2) with glycine and encapsulated into native beta-CD, a hydroxypropylated derivative HPbetaCD, and the methylated cyclodextrins TRIMEB and CRYSMEB. All four inclusion compounds were obtained with a 1:1 host:guest stoichiometry and characterised in the solid-state by powder X-ray diffraction, th...