3 documents found, page 1 of 1
A physiology-based mathematical model to understand drug delivery from contact ...
Toffoletto, Nadia; Saramago, Benilde; Serro, Ana Paula; Chauhan, AnujObjective: Therapeutic contact lenses, able to store drug and deliver it to the eye surface in a sustained fashion, gained interest as an effective and patient-friendly alternative to eye drops. Recent animal studies also demonstrated the presence of therapeutic drug levels in the back of the eye after wearing drug-loaded contact lenses, thus opening the possibility of treating the posterior segment without nee...
Asymmetry in drug permeability through the cornea
Toffoletto, Nadia; Chauhan, Anuj; Alvarez-Lorenzo, Carmen; Saramago, Benilde; Serro, Ana PaulaThe permeability through the cornea determines the ability of a drug or any topically applied compound to cross the tissue and reach the intraocular area. Most of the permeability values found in the literature are obtained considering topical drug formulations, and therefore, refer to the drug permeability inward the eye. However, due to the asymmetry of the corneal tissue, outward drug permeability constitute...
Controlled release of antibiotics from vitamin E–loaded silicone-hydrogel conta...
Paradiso, Patrizia; Serro, Ana Paula; Saramago, Benilde; Colaço, Rogério; Chauhan, AnujSymptoms of bacterial and fungal keratitis are typically treated through the frequent application of antibiotic and antifungal eye drops. The high frequency of half hourly or hourly eye drop administration required to treat these indications is tedious and could reduce compliance. Here, we combine in vitro experiments with a mathematical model to develop therapeutic soft contact lenses to cure keratitis by exte...