46 documents found, page 1 of 5
Customizing 3D structures of vertically aligned carbon nanotubes to direct neur...
Nascimento, Luís; Fernandes, Cristiana; Silva, Ricardo M.; Semitela, Ângela; Sousa, Bárbara M. de; Marques, Paula A. A. P.; Vieira, Sandra I.Neural tissue-related illnesses have a high incidence and prevalence in society. Despite intensive research efforts to enhance the regeneration of neural cells into functional tissue, effective treatments are still unavailable. Here, a novel therapeutic approach based on vertically aligned carbon nanotube forests (VA-CNT forests) and periodic VA-CNT micropillars produced by thermal chemical vapor deposition is ...
Decellularized extracellular matrix-based 3D nanofibrous scaffolds functionaliz...
Silva, Daniela M. da; Barroca, Nathalie; Pinto, Susana C.; Semitela, Ângela; de Sousa, Bárbara M.; Martins, Patrícia A. D.One of the exciting prospects of using decellularized extracellular matrices (ECM) lies in their biochemical profile of preserved components, many of which are regeneration-permissive. Herein, a decellularized ECM from adipose tissue (adECM) was explored to design a scaffolding strategy for the challenging repair of the neural tissue. Targeting the recreation of the nano-scaled architecture of native ECM, adECM...
Bio-electrospraying assessment toward in situ chondrocyte-laden electrospun sca...
Semitela, Ângela; Ramalho, Gonçalo; Capitão, Ana; Sousa, Cátia; Mendes, Alexandrina F.; Marques, Paula A. A. P.; Completo, AntónioElectrospinning has been widely used to fabricate fibrous scaffolds for cartilage tissue engineering, but their small pores severely restrict cell infiltration, resulting in an uneven distribution of cells across the scaffold, particularly in three-dimensional designs. If bio-electrospraying is applied, direct chondrocyte incorporation into the fibers during electrospinning may be a solution. However, before th...
Bio-electrospraying assessment toward in situ chondrocyte-laden electrospun sca...
Semitela, Ângela; Ramalho, Gonçalo; Capitão, Ana; Sousa, Cátia; Mendes, Alexandrina F.; Marques, Paula A. A. P.; Completo, AntónioElectrospinning has been widely used to fabricate fibrous scaffolds for cartilage tissue engineering, but their small pores severely restrict cell infiltration, resulting in an uneven distribution of cells across the scaffold, particularly in three-dimensional designs. If bio-electrospraying is applied, direct chondrocyte incorporation into the fibres during electrospinning may be a solution. However, before th...
Effects of graphene oxide nanosheets in the polychaete Hediste diversicolor: be...
Pires, Adília; Figueira, Etelvina; Silva, M. S. S.; Sá, Carina; Marques, Paula A. A. P.Numerous applications exist for graphene-based materials, such as graphene oxide (GO) nanosheets. Increased concentrations of GO nanosheets in the environment have the potential to have a large negative effect on the aquatic environment, with consequences for benthic organisms, such as polychaetes. The polychaete Hediste diversicolor mobilises the sediments, hence altering the availability of contaminants and t...
Effects of Graphene Oxide and Reduced Graphene Oxide Nanostructures on CD4+ Th2...
Feito, María José; Cicuéndez, Mónica; Casarrubios, Laura; Diez-Orejas, Rosalía; Fateixa, Sara; Silva, Daniela; Nathalie Barroca; Marques, Paula A. A. P.The activation of T helper (Th) lymphocytes is necessary for the adaptive immune response as they contribute to the stimulation of B cells (for the secretion of antibodies) and macrophages (for phagocytosis and destruction of pathogens) and are necessary for cytotoxic T-cell activation to kill infected target cells. For these issues, Th lymphocytes must be converted into Th effector cells after their stimulatio...
Boosting in vitro cartilage tissue engineering through the fabrication of polyc...
Semitela, Ângela; Girão, André F.; Fernandes, Carla; Ramalho, Gonçalo; Pinto, Susana C.; Completo, António; Marques, Paula A. A. P.Due to the limited self-healing ability of natural cartilage, several tissue engineering strategies have been explored to develop functional replacements. Still, most of these approaches do not attempt to recreate in vitro the anisotropic organization of its extracellular matrix, which is essential for a suitable load-bearing function. In this work, different depth-dependent alignments of polycaprolactone-gelat...
High affinity of 3D spongin scaffold towards Hg(II) in real waters
Domingues, Eddy M.; Gonçalves, Gil; Henriques, Bruno; Pereira, Eduarda; Marques, Paula A. A. P.This study focuses on the ability of commercial natural bath sponges, which are made from the skeletons of marine sponges, to sorb Hg from natural waters. The main component of these bath sponges is spongin, which is a protein-based material, closely related to collagen, offering a plenitude of reactive sites from the great variety of amino acids in the protein chains, where the Hg ions can sorb. For a dose of ...
How efficient is graphene-based nanocomposite to adsorb Hg from seawater: a lab...
Coppola, Francesca; Jiang, Weiwei; Soares, Amadeu M. V. M.; Marques, Paula A. A. P.; Polese, Gianluca; Pereira, Maria Eduarda; Jiang, ZengjieAdvanced investigations on the use of graphene based nanomaterials have highlighted the capacity of these materials for wastewater treatment. Research on this topic revealed the efficiency of the nanocomposite synthetized by graphene oxide functionalized with polyethyleneimine (GO-PEI) to adsorb mercury (Hg) from contaminated seawater. However, information on the environmental risks associated with these approa...
A multifactorial approach to untangle graphene oxide (GO) nanosheets effects on...
Lopes, Tiago; Cruz, Catarina; Cardoso, Paulo; Pinto, Ricardo; Marques, Paula A. A. P.; Figueira, EtelvinaDrought is a limiting factor for agricultural productivity. Climate change threatens to expand the areas of the globe subjected to drought, as well as to increase the severity and duration of water shortage. Plant growth-promoting bacteria (PGPB) are widely studied and applied as biostimulants to increase plant production and to enhance tolerance to abiotic and biotic constraints. Besides PGPB, studies on the p...