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Severe acute kidney injury in hospitalized cancer patients: epidemiology and pr...

Marques, Roberto Calças; Reis, Marina; Pimenta, Gonçalo; Sala, Inês; Chuva, Teresa; Coelho, Inês; Ferreira, Hugo; Paiva, Ana; Costa, José Maximino

Background: Acute kidney injury (AKI) is a common complication among cancer patients, often leading to longer hospital stays, discontinuation of cancer treatment, and a poor prognosis. This study aims to provide insight into the incidence of severe AKI in this population and identify the risk factors associated with renal replacement therapy (RRT) and in-hospital mortality. Methods: This retrospective cohort st...


Peritoneal protein loss with time in peritoneal dialysis

Guedes, Anabela Malho; Marques, Roberto Calças; Domingos, Ana Teresa; Laranjo, Céu; Silva, Ana Paula; Rodrigues, Anabela; Krediet, Raymond T.

Longitudinal evolution of peritoneal protein loss (PPL), a reflection of hydrostatic pressure-driven leak of plasma proteins through the large-pore pathway, is not clear. Time on PD causes loss of mesothelial cells, vasculopathy, and increased thickness of the submesothelial fibrous layer. Are these structural changes associated with progressive increase of PPL, in a parallel with the rise in the D/P creatinine...


Calcium/magnesium ratio in patients with diabetes and chronic kidney disease: a...

Borges, Henrique; Afonso, Rita; Marques, Roberto Calças; Jerónimo, Teresa; Silva, Ana

Chronic Kidney Disease (CKD) and Diabetes Mellitus (DM) are significant risk factors for Cardiovascular (CV) Disease. Patients with CKD and/or DM exhibit higher incidence and prevalence of CV events compared to the general population. Hypomagnesemia and elevated calcium-magnesium (Ca:Mg) ratios have been identified as independent risk factors for CV-related deaths. The aim of this study is to determine the rela...


Ascites, pleural, and pericardial effusion in primary hypothyroidism: a rare ca...

Santos, Pedro Gomes; Marques, Roberto Calças; Santos, Pedro Martins dos; Costa, Catarina Carreira da; Mogildea, Mihail

Hypothyroidism is caused by a deficiency of thyroid hormones and is a common endocrine disorder worldwide. It can affect nearly every organ, resulting in multiple clinical manifestations. Ascites, pleural effusion, and pericardial effusion, although less frequent than peripheral edema, can also be present. These manifestations are thought to be caused by increased vascular permeability to albumin, extravasation...


Tratamento do linfoma de Hodgkin em estadio avançado : proposta de algoritmo

Marques, Roberto Calças

O Linfoma de Hodgkin (LH) é um dos cancros com maior potencial de cura, mesmo em estadio avançado, cuja terapêutica de primeira linha se baseia em diversos regimes de quimioterapia (QT), nomeadamente o ABVD (Doxorrubicina, Bleomicina, Vimblastina e Dacarbazina), associados ou não a radioterapia (RT). Nas fases tardias da doença, o esquema BEACOPP (Bleomicina, Etoposido, Doxorrubicina, Ciclofosfamida, Vincristin...


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