7 documents found, page 1 of 1
A short-term exposure to saxitoxin triggers a multitude of deleterious effects ...
Pinto, Albano; Macário, Inês P. E.; Marques, Sérgio M.; Lourenço, Joana; Domingues, Inês; Botelho, Maria João; Asselman, Jana; Pereira, PatríciaHarmful algal blooms and the toxins produced during these events are a human and environmental health concern worldwide. Saxitoxin and its derivatives are potent natural aquatic neurotoxins produced by certain freshwater cyanobacteria and marine algae species during these bloom events. Saxitoxins effects on human health are well studied, however its effects on aquatic biota are still largely unexplored. This wo...
Copper sulphate impact on the antioxidant defence system of the marine bivalves...
Mesquita, Andreia F.; Marques, Sérgio M.; Marques, João C.; Gonçalves, Fernando J. M.; Gonçalves, Ana M. M.Anthropogenic activities, such as agriculture and industrial activities, are a main source of pollution contributing for the degradation of water quality and thus affecting the living organisms of aquatic systems. Copper is widely used at these practices being often released into the aquatic systems and may cause negative effects in its communities. This study proposes to determine the effects of copper in the ...
Diversidade e sensibilidade da microbiota da pele de rãs de um local contaminad...
Gonçalves, Ana C. D.; Figueiredo, Daniela; Pereira, Ruth; Gonçalves, Fernando; Marques, Sérgio M.A microbiota da pele dos anfíbios é considerada parte do seu sistema imunitário já com provas dadas de inclusivamente poder inibir o fungo patogénico Batrachochytrium dendrobatidis. A composição do microbiota pode variar entre locais dependendo de vários parâmetros ambientais. Considerando que alguns contaminantes como os metais são persistentes, podendo afetar as comunidades bacterianas, e que inclusivamente a...
Design, synthesis and neuroprotective evaluation of novel tacrine–benzothiazole...
Keri, Rangappa S.; Quintanova, Catarina; Marques, Sérgio M.; Esteves, A. Raquel; Cardoso, Sandra M.; Santos, M. AméliaAlzheimer’s disease (AD) is a multifactorial disorder with several target proteins contributing to its etiology. In search for multifunctional anti-AD drug candidates, taking into account that the acetylcholinesterase (AChE) and beta-amyloid (Aβ) aggregation are particularly important targets for inhibition, the tacrine and benzothiazole (BTA) moieties were conjugated with suitable linkers in a novel series of ...
Differential gene expression in Iberian green frogs (Pelophylax perezi) inhabit...
Marques, Sérgio M.; Chaves, Sandra; Gonçalves, Fernando; Pereira, RuthIberian green frogs (Pelophylax perezi) were found inhabiting a deactivated uranium mine, especially an effluent pond, seriously contaminated with metals and radionuclides. These animals were previously assessed for oxidative stress parameters and did not revealed significant alterations. In order to better understand which mechanisms may be involved in the ability to withstand permanent contamination gene expr...
Evaluation of growth, biochemical and bioaccumulation parameters in Pelophylax ...
Marques, Sérgio M.; Chaves, Sandra; Gonçalves, Fernando; Pereira, RuthMining activities invariably produce metal contaminated effluents. Depending on factors such as pH and metal concentration the toxicity of the effluent may vary. To assess the effects of three characteristically different effluent ponds from a deactivated uranium mine, with toxicologically relevant data, an in situ exposure with Pelophylax perezi tadpoles, was conducted. Tadpoles were exposed to the three efflu...
Antioxidant response and metal accumulation in tissues of Iberian green frogs (...
Marques, Sérgio M.; Antunes, Sara C.; Nunes, Bruno; Gonçalves, Fernando; Pereira, RuthHuman mining activities tend often to generate greatly impacted areas which remain contaminated for long periods of time, giving rise to extreme habitats. Mining sites are usually characterized for the production of metal rich effluents with very low pH. In this work we analyzed physical and chemical parameters of water from a deactivated uranium mine pond (M) and a reference site (REF) as well as their metal co...