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ALCALOIDES ACRIDÔNICOS INIBEM CATEPSINA L E V
Marques,Emerson F.; Vieira,Paulo C.; Severino,Richele P.Cathepsins represent a class of enzymes that has the primary function of randomly degrading proteins in the lysosomes, although are also involved in different pathologies. The aim of this paper was to evaluate the capacity of acridone alkaloids isolated from Swinglea glutinosa (Rutaceae) to inhibit cathepsin L in vitro . The IC50 values found were in the 0.8-57 µM range and the most promising compounds were alk...
Date: 2016
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Origin: Oasisbr