7 documents found, page 1 of 1
Total synthesis and allelopathic activity of cytosporones A-C
Zamberlam,Charles E. M.; Meza,Alisson; Leite,Carla Braga; Marques,Maria Rita; de Lima,Dênis P.; Beatriz,AdilsonThe search for efficient, environmentally friendly herbicides has been the focus of numerous studies on the organic synthesis of compounds isolated from natural sources. Cytosporones, which are phenolic lipids isolated from fungi, exhibit noteworthy biological properties. This paper reports the preparation of cytosporones A-C from the same starting material through a short synthetic route, with good yields. All...
In vitro cytotoxic activity of Brazilian Middle West plant extracts
Mahmoud,Talal Suleiman; Marques,Maria Rita; Pessoa,Cláudia do Ó; Lotufo,Leticia V. C.; Magalhães,Hemerson I. F.; Moraes,Manoel O. de; Lima,Dênis P. deCytotoxic activity of eight plant extracts, native from the Mid-West of Brazil comprising Cerrado, Pantanal and semideciduous forest, was evaluated for MDA-MB-435, SF-295, and HCT-8 cancer cell strains. A single 100 µg.mL-1 dose of each extract was employed with 72 h of incubation for all tests. Doxorubicin (1 µg.mL-1) was used as the positive control and the MTT method was used to detect the activity. Cytotoxi...
Biotransformation of a cage-like diels-alder adduct and derivatives by Mucor ra...
Ito,Felicia Megumi; Mena,Ana Elisa Maciel; Marques,Maria Rita; Lima,Dênis Pires de; Beatriz,AdilsonThe present study aimed to evaluate the ability for biotransformation of the Diels-Alder adduct tricyclo[6.2.1.0(2,7)]undeca-4,9-dien-3,6-dione (1) and two synthetic derivatives by the saprobe fungus Mucor ramosissimus Samutsevitsch. Products from oxidation, isomerization and, regioselective and enantioselective reduction were achieved.
Synthesis of resorcinolic lipids bearing structural similarities to cytosporone A
Santos,Edson dos Anjos dos; Beatriz,Adilson; Lima,Dênis Pires de; Marques,Maria Rita; Leite,Carla BragaInspired by the structure and biological activities of resorcinolic lipids and, particularly cytosporone A- a potent inhibitor of plantule germination and growth, we have performed the synthesis of the analogs 3-heptyl-3-hydroxy-5,7-dimethoxy-2-benzofuran-1(3H)-one (1) and 3-heptyl-3-hydroxy-4,6-dimethoxy-2-benzofuran-1(3H)-one (2). The intermediates and products were submitted to allelopathic test using Lactuc...
Insetos visitantes de gomas exsudadas por Terminalia argentea Mart & Zucc (...
Boff,Samuel; Graciolli,Gustavo; Boaretto,Amanda Galdi; Marques,Maria RitaUma das fontes efêmeras de alimento que os insetos podem utilizar são as gomas exsudadas por plantas. No mês de maio de 2005, em uma área de cerrado no município de Campo Grande, Mato Grosso do Sul, foram observados insetos visitando as estruturas de exsudação em um indivíduo de Terminalia agentea Mart & Zucc (Combretaceae). Foram registradas 19 espécies, principalmente Trigona branneri (Cockerell) e Mesemb...
Bioactive derivatives obtained from lecanoric acid, a constituent of the lichen...
Gomes,Alcir Teixeira; Honda,Neli K.; Roese,Fernanda Mesquita; Muzzi,Rozanna M.; Marques,Maria RitaWith the aim of obtaining new compounds with potential antifungal activity, lecanoric acid, a chemical constituent of the lichen Parmotrema tinctorum and its derivatives prepared from structural modification were tested against the fungus Cladosporium sphaerospermum, by employing the bioautographic method. Activity of the derivatives ranged from 10- to 1-μg concentrations. Results demonstrated this series of co...
Transformações químicas do (+)-10b,14-diol-allo-aromadendrano, isolado de dugue...
Lima,Dênis Pires de; Beatriz,Adilson; Ramos,Alexandre Ayoroa; Siqueira,João Máximo de; Oliveira,Celso Corrêa de; Marques,Maria RitaThe sesquiterpene (+)-allo-aromadendrane-10b-14-diol 1 was the lead compound to the preparation of several derivatives in order to test their biological activity against A. salina, C. sphaerospermum, E. coli and S. aureus. In this way the monoalcohols (+)-viridiflorol 4, 9 and 11 were synthesized from 1 together with the acetal 6, the ketal 7, and the ketone 8. The oxirane 3 and nitrile 5 were also prepared usi...