Funding Information: Open access funding provided by FCT|FCCN (b-on). Centro Acad\u00E9mico Cl\u00EDnico\u2014Egas Moniz Health Alliance,University of Aveiro,Portugal Publisher Copyright: © The Author(s) 2025.; Central precocious puberty (CPP) diagnosis often requires invasive GnRH stimulation tests. Our purpose was to determine whether the IGF-1 and IGF-1 SDSs are reliable predictors of progressive CPP. This w...