5 documents found, page 1 of 1
Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease...
Chegão, Ana; Guarda, Mariana; Alexandre, Bruno M.; Shvachiy, Liana; Temido Ferreira, Mariana; Marques-Morgado, Inês; Fernandes Gomes, BárbaraAlpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to its accumulation in typical protein aggregates in the brain. However, it is still unclear how it contributes to neurodegeneration. Type-2 diabetes mellitus is a risk factor for Parkinson's disease (PD). Interestingly, a common molecular alteration among these disorders is the age-associated increase in protein glycation. ...
Transection of the superior sagittal sinus enables bilateral access to the rode...
Dias, Marcelo; Marques-Morgado, Inês; Coelho, Joana E; Ruivo, Pedro; Lopes, Luisa V.; Remondes, MiguelStereotaxic access to brain areas underneath the superior sagittal sinus (SSS) is notoriously challenging. As a major drainage vessel, covering the whole extension of the sagittal fissure, the SSS impedes direct bilateral access to underlying regions for recording and stimulation probes, drug-delivery cannulas, and injection devices. We now describe a new method for transection and retraction of the SSS in rats...
Adenosine receptors as neuroinflammation modulators: role of A1 agonists and A2...
Martí Navia, Aleix; Dal Ben, Diego; Lambertucci, Catia; Spinaci, Andrea; Volpini, Rosaria; Marques-Morgado, Inês; Coelho, Joana E; Lopes, Luisa V.The pathological condition of neuroinflammation is caused by the activation of the neuroimmune cells astrocytes and microglia. The autacoid adenosine seems to be an important neuromodulator in this condition. Its main receptors involved in the neuroinflammation modulation are A1AR and A2AAR. Evidence suggests that A1AR activation produces a neuroprotective effect and A2AARs block prevents neuroinflammation. The...
Age-related shift in LTD is dependent on neuronal adenosine A2A receptors inter...
Temido Ferreira, Mariana; Ferreira, Diana; Batalha, Vânia; Marques-Morgado, Inês; Coelho, Joana E; Pereira, Pedro; Gomes, Rui; Pinto, AndreiaSynaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drives the cognitive decline. An association between a polymorphism of the adenosine A2A receptor (A2AR) encoding gene-ADORA2A, and hippocampal volume in AD patients was recently described. In this study, we explore the synaptic function of A2AR in age-related conditions. We report, for the first time, a significant overexpression o...
α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 a...
Ferreira, Diana; Temido Ferreira, Mariana; Vicente Miranda, Hugo; Batalha, Vânia; Coelho, Joana E; Szegö, Éva M; Marques-Morgado, Inês; Vaz, Sandra H.Synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, are neurodegenerative disorders that are characterized by the accumulation of α-synuclein (aSyn) in intracellular inclusions known as Lewy bodies. Prefibrillar soluble aSyn oligomers, rather than larger inclusions, are currently considered to be crucial species underlying synaptic dysfunction. We identified the cellular prion protein ...