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SARS-CoV-2 Membrane Protein: From Genomic Data to Structural New Insights

Marques-Pereira, Catarina; Pires, Manuel N.; Gouveia, Raquel P.; Pereira, Nádia N.; Caniceiro, Ana B.; Rosário-Ferreira, Nícia; Moreira, Irina S.

Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) is composed of four structural proteins and several accessory non-structural proteins. SARS-CoV-2's most abundant structural protein, Membrane (M) protein, has a pivotal role both during viral infection cycle and host interferon antagonism. This is a highly conserved viral protein, thus an interesting and suitable target for drug discovery. In this pa...


The Role of Serratomolide-like Amino Lipids Produced by Bacteria of Genus Serra...

Marques-Pereira, Catarina; Proença, Diogo Neves; Morais, Paula V.

Bursaphelenchus xylophilus, also known as pinewood nematode (PWN), is the pathogenic agent of pine wilt disease (PWD), which affects pine trees around the world. Infection spread globally through international wood commerce and locally by vector beetles, threatening the wood world economy. As climate changes, more countries are becoming susceptible to PWD and, to prevent disease spread and limit economic and ec...


Genome Sequences of Serratia Strains Revealed Common Genes in Both Serratomolid...

Marques-Pereira, Catarina; Proença, Diogo Neves; Morais, Paula V.

Serratia strains are ubiquitous microorganisms with the ability to produce serratomolides, such as serrawettins. These extracellular lipopeptides are described as biocides against many bacteria and fungi and may have a nematicidal activity against phytopathogenic nematodes. Serrawettins W1 and W2 from different strains have different structures that might be correlated with distinct genomic organizations. This ...


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