75 documents found, page 1 of 8
Interpretable Machine Learning for Stroke Recovery
Augusto, Inês; António, Nuno; Marreiros, Ana; Ramalhete, Sara Ventura; Nzwalo, HipólitoIntroduction Stroke is a leading cause of disability worldwide. This study uses Machine Learning models to investigate factors influencing modified Rankin Scale scores at discharge and three months post-discharge. Methods Data from 116 stroke patients were analyzed using four predictive models: Logistic Regression, Support Vector Machine, Random Forest, and Extreme Gradient Boosting (XGB). Shapley Additive Expl...
A morphometric characterization of early CHICK embryo elongation
Maia-Fernandes, Ana C; Pais de Azevedo, Tomás; Martins, Nísia Borralho; Ventura Ramalhete, Sara Maria; Martins, G. G.; Palmeirim, IsabelThe chicken embryo has long been a pivotal model system to understand the cellular and molecular mechanisms driving amniote embryo development. Its easy access for in vivo experimentation, together with the development of ex ovo culture techniques, has made it a choice model system for elaborate experimental manipulations. Temporal progression of chick embryo development is classically categorized using the Ham...
zAvatar-test—a functional precision model to personalize ovarian cancer treatme...
Estrada, Marta F.; Amorim, Filipa; Silva, Filipa Ferreira da; Almeida, Cátia Rebelo de; Fontes, Márcia; Coelho, Ricardo; Ferreira, SóniaIn ovarian cancer, 80% of patients relapse after first-line therapy. In recurrent cases, oncologists lack reliable tests to guide chemotherapy choices, creating an unmet clinical need. Here, we develop the ovarian cancer zebrafish Avatar-test, a functional in vivo model using patient tumor cells implanted in zebrafish embryos to predict treatment responses. We present the largest observational study (32 patient...
Smart Triage
Ramalhete, Sara Ventura; António, Nuno; Marreiros, Ana; Nzwalo, HipólitoBackground Stroke is a leading cause of death and disability worldwide where “time is brain”. Thrombolysis is the most common treatment and is available in all certified hospitals. Otherwise, thrombectomy is not available in all hospitals, but it is the most effective treatment. Nevertheless, current guidelines determine that stroke patients must be transported to the nearest hospital without considering the av...
Impact of a Mediterranean-Inspired Diet on Cardiovascular Disease Risk Factors:...
Barbosa, Ana; Pais, Sandra; Marreiros, Ana; Correia, MartaAbstract: Cardiovascular diseases (CVDs) are the leading cause of death worldwide. This study focused on evaluating the impact of a Mediterranean-type diet combined with physical exercise on CVD risk factors of high-risk individuals. A randomized clinical trial (RCT) recruited individuals (≥50 years old) with no history of acute myocardial infarction, but with high CVD risk criteria according to the SCORE2/SCOR...
Impact of a Mediterranean-Inspired Diet on Cardiovascular Disease Risk Factors:...
Barbosa, Rita; Pais, Sandra; Marreiros, Ana; Correia, MartaAbstract: Cardiovascular diseases (CVDs) are the leading cause of death worldwide. This study focused on evaluating the impact of a Mediterranean-type diet combined with physical exercise on CVD risk factors of high-risk individuals. A randomized clinical trial (RCT) recruited individuals (≥50 years old) with no history of acute myocardial infarction, but with high CVD risk criteria according to the SCORE2/SCOR...
Reinfection incidence following surgical intervention for infected aortic bypas...
Brazuna, Márcio; Costa, Marta Gonçalves; Marreiros, Ana; Andrade, Leonardo Araújo; Andrade, José Paulo; Neves, João RochaBackground Infection of vascular grafts after aortic revascularization surgery is a serious complication with high morbid ity and mortality. This systematic review and meta-analysis aims to determine reinfection incidence in patients undergoing surgical intervention for infected aortic bypass grafts and identify key risk factors in the literature. Materials and Methods This systematic review and meta-analysis f...
Association of acute COVID-19 severity and long COVID fatigue and quality of li...
Pires, Ligia; Marreiros, Ana; Saraiva, Cátia; Reis, Cláudia; Neves, Djamila; Guerreiro, Cláudia; Tomé, José Boleo; Luz, Maria InêsLong COVID, or post-COVID-19 condition, is characterized by symptoms persisting beyond 12 weeks after severe acute respiratory syndrome coronavirus 2 infection, affecting individuals regardless of acute disease severity. Fatigue – often linked with depression and anxiety – is among its most debilitating manifestations. However, the associations between fatigue subtypes (physical vs mental), mental health sympto...
Clinical and epidemiological characteristics of patients with functional stroke...
Figueira Domingos, Miguel; Silva, Vítor Hugo; Schuh, Sara; Correia, Helena; Palma, Pedro; Pedro, João Pedroso; Nova, Bruno Vila; Marreiros, AnaBackground: Patients with functional neurological disorder presenting as stroke mimics or functional stroke mimics (FSMs) pose significant diagnostic challenges. In the acute phase, especially when patients are present within the therapeutic window for acute reperfusion treatments, a misdiagnosis of FSM can lead to unnecessary and costly interventions. Despite its clinical importance, the literature on the risk...
Avaliação do tratamento intra-articular com solução de proteína autóloga em equ...
Marreiros, Ana; Fino, Tomé; Roda, Rute; Monteiro, SusanaIntrodução e objetivos: A solução de proteína autóloga (APS) é uma terapia anti-inflamatória que contém uma elevada concentração de fatores de crescimento e que, gradualmente, se tem tornado uma opção de interesse na medicina de equinos, canídeos e do homem. Considerando a escassa bibliografia atualmente disponível, o presente estudo retrospetivo pretendeu avaliar os efeitos da APS no tratamento de equinos com ...