15 documents found, page 1 of 2
Melatonin effects on pulmonary tissue in the experimental model of Hepatopulmon...
Bosco,Adriane Dal; Schedler,Filipe Boeira; Colares,Josieli Raskopf; Schemitt,Elisângela Gonçalves; Hartmann,Renata MinuzzoABSTRACT Objective: To evaluate the pulmonary alterations of animals with Hepatopulmonary Syndrome (HPS) submitted to Biliary Duct Ligature (BDL), as well as the antioxidant effect of Melatonin (MEL). Methods: Sixteen male Wistar rats, divided into four Sham groups: BDL group, Sham + MEL group and BDL + MEL. The pulmonary and hepatic histology, lipoperoxidation and antioxidant activity of lung tissue, alveolar-...
The effects of local ischemic preconditioning and topical hypothermia in renal ...
Ribeiro,Guilherme Behrend; Santos,Emanuel Burck dos; Bona,Silvia Regina; Schaefer,Pedro Guilherme; Garcez,Tuane Alves; Rabolini,Eduardo BrasilAbstract Purpose: Topical hypothermia and local ischemic preconditioning have been shown to reduce renal ischemia-reperfusion (I/R) injury individually. We examined whether combination of both strategies lessens renal I/R injury. Methods: Post right nephrectomy, 40 male Wistar rats were randomly assigned to five experimental protocols performed in the left kidney: topical hypothermia without ischemia (TH), warm...
Effect of lecithin on oxidative stress in an experimental model of rats colitis...
Colares,Josieli Raskopf; Schemitt,Elizângela Gonçalves; Hartmann,Renata Minuzzo; Moura,Rosa Maria; Morgan-Martins,Maria IsabelAbstract Ulcerative colitis (UC) is an inflammatory disease that affects the bowels. Reactive oxygen species (ROS) are involved in the progress of UC. Objective Evaluate the antioxidant effect of lecithin in an experimental model of acute UC induced by administration of acetic acid (AA) in rats. Methods Lecithin (0.5 mL/kg/day) administered orally 2 days before and after induction of colitis with 4% AA in a vol...
Antioxidant effect of mesalazine in the experimental colitis model induced by a...
Moura,Rosa Maria; Hartmann,Renata Minuzzo; Licks,Francielli; Schemitt,Elizângela Gonçalves; Colares,Josieli Raskopf; do Couto Soares,MarianaAbstract Introduction Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the gastrointestinal tract, without specific cause or pathogen. Objective The effect of mesalazine in a colitis model induced by acetic acid (AA) was evaluated. Methods We used 40 Wistar rats, ±350 g, divided into 4 groups: control (CO); control + mesalazine (CO + M); colitis (CL) and colitis + M (CL + M) at 24 ...
Inflammatory bowel and oxidative stress changes in an experimental model of por...
Licks,Francielli; Hartmann,Renata Minuzzo; Schemitt,Elizângela; Colares,Josieli Raskopf; Fillmann,Lúcio Sarubbi; Fillmann,Henrique; Marroni,Norma PossaABSTRACT Introduction: Portal hypertension (PH) is characterized by vasodilatation in the portal system and the bowel is one of the severely affected organs. N-acetylcysteine (NAC) is a molecule with important properties and widely used in clinical practice. Objective: To evaluate NAC action in the bowel of animals submitted to the animal model of partial portal vein ligation (PPVL). Methods: 18 male Wistar rat...
Melatonin prevents hyperglycemia in a model of sleep apnea
Kaminski,Renata Schenkel Rivera; Martinez,Denis; Fagundes,Micheli; Martins,Emerson Ferreira; Montanari,Carolina Caruccio; Rosa,Darlan PaseObjective Obstructive sleep apnea is a common disorder associated with aging and obesity. Apneas cause repeated arousals, intermittent hypoxia, and oxidative stress. Changes in glucolipidic profile occur in apnea patients, independently of obesity. Animal models of sleep apnea induce hyperglycemia. This study aims to evaluate the effect of the antioxidants melatonin and N-acetylcysteine on glucose, triglyceride...
Os efeitos da ventilação mecânica no estresse oxidativo
Mazullo Filho,João Batista Raposo; Bona,Silvia; Rosa,Darlan Pase da; Silva,Fabiano Gomes da; Forgiarini Junior,Luiz Alberto; Dias,Alexandre SimõesOBJETIVO: A ventilação mecânica constitui um dos pilares terapêuticos da unidade de terapia intensiva, entretanto, deve-se avaliar os efeitos deletérios por ela ocasionados, logo objetivamos avaliar o estresse oxidativo de pacientes internados em unidade de terapia intensiva submetidos à ventilação mecânica invasiva. MÉTODOS: Estudo transversal onde foram incluídos 12 pacientes que estavam em ventilação mecânic...
Methionine- and choline-deficient diet induces hepatic changes characteristic o...
Marcolin,Éder; Forgiarini,Luiz Felipe; Tieppo,Juliana; Dias,Alexandre Simões; Freitas,Luiz Antonio Rodrigues de; Marroni,Norma PossaCONTEXT: Non-alcoholic steatohepatitis is a disease with a high incidence, difficult diagnosis, and as yet no effective treatment. So, the use of experimental models for non-alcoholic steatohepatitis induction and the study of its routes of development have been studied. OBJECTIVES: This study was designed to develop an experimental model of non-alcoholic steatohepatitis based on a methionine- and choline-defic...
Protection of estrogen in portal hypertension gastropathy: an experimental model
Morgan-Martins,Maria Isabel; Jacques,Simone Iahnig; Hartmann,Renata Minuzzo; Marques,Camila Moraes; Marroni,Cláudio Augusto; Marroni,Norma PossaCONTEXT: Portal hypertension is a complication secondary to cirrhosis that is characterized by increased blood flow and/or vascular resistance in the portal system, causing the appearance of a hyperdynamic collateral circulation. Partial portal vein ligation is an experimental model used in rats to study the pathophysiological mechanisms involved in pre-hepatic portal hypertension. Estrogen E2 is an antioxidant...
Melatonin protects the liver and erythrocytes against oxidative stress in cirrh...
Rosa,Darlan Pase da; Bona,Silvia; Simonetto,Douglas; Zettler,Claudio; Marroni,Cláudio Augusto; Marroni,Norma PossaCONTEXT: Cirrhosis is a progressive chronic hepatopathy which constitutes an irreversible stage of liver dysfunction. OBJECTIVES: To evaluate the oxidative stress in the blood of cirrhotic rats treated with the antioxidant melatonin. METHODS: Cirrhosis was induced through inhalation of carbon tetrachloride. Liver integrity was evaluated by measuring serum enzymes, oxidative damage measured by lipoperoxidation, ...