7 documents found, page 1 of 1
Mesoporous silica nanoparticles with manganese and lanthanide salts: synthesis,...
Forte, Andreia; Gago, Sandra; Ribeiro Carrott, Manuela; Carrott, Peter; Alves, Celso; Teodoro, Fernando; Pedrosa, Rui; Marrucho, Isabel; Branco, LuísSeveral organic salts based on the combination of two different choline derivative cations and [MnCl3]-, [GdCl4]- and [TbCl4]- as anions, were immobilized in mesoporous silica nanoparticles (MSNs) by a two-step synthetic method. Firstly, MSNs were functionalized with choline derivative cations with chloride anions and then the metals were incorporated by the reaction of the chloride with the respective metal ch...
Evaluation of solubility and partition properties of ampicillin-based ionic liq...
Florindo, Catarina; Araújo, João; Alves, Filipa; Matos, Carla; Ferraz, Ricardo; Prudêncio, Cristina; Noronha, João Paulo; Petrovski, ZeljkoIn order to overcome the problems associated with low water solubility, and consequently low bioavailability of active pharmaceutical ingredients (APIs), herein we explore a modular ionic liquid synthetic strategy for improved APIs. Ionic liquids containing l-ampicillin as active pharmaceutical ingredient anion were prepared using the methodology developed in our previous work, using organic cations selected fr...
Development of novel ionic liquids based on valproate anion
Ferraz, Ricardo; Costa, Alexandra; Marrucho, Isabel; Branco, Luís; Prudêncio, Cristina; Noronha, João Paulo; Petrovski, ZeljkoValproic acid (2-propyl pentanoic acid) is a pharmaceutical drug used for treatment of epileptic seizures absence, tonic-clonic (grand mal), complex partial seizures, and mania in bipolar disorder [1]. Valproic acid is a slightly soluble in water and therefore as active pharmaceutical ingredient it is most commonly applied in form of sodium or magnesium valproate salt [1].However the list of adverse effects of ...
Development of novel ionic liquids based on ampicillin
Ferraz, Ricardo; Prudêncio, Cristina; Branco, Luís; Marrucho, Isabel; Araújo, João; Rebelo, Luís; Ponte, Manuel Nunes; Noronha, João PauloNovel ionic liquids containing ampicillin as an active pharmaceutical ingredient anion were prepared with good yields by using a new, efficient synthetic procedure based on the neutralization of a moderately basic ammonia solution of ampicillin with different organic cation hydroxides. The relevant physical and thermal properties of these novel ionic liquids based on ampicillin were also evaluated.
Synthesis, characterization and antiproliferative activity on cancer cell lines...
Ferraz, Ricardo; Costa-Rodrigues, João; Fernandes, Maria Helena; Branco, Luís; Marrucho, Isabel; Ponte, Manuel Nunes; Prudêncio, CristinaIonic Liquids (ILs) are ionic compounds that possess melting temperature below 100ºC and they have been a topic of great interest since the mid-1990s due to their unique properties. The range of IL uses has been broadened, due to a significant increase in the variety of physical, chemical and biological ILs properties. They are now used as Active Pharmaceutical Ingredients (APIs) and recent interests are focuse...
New ionic liquids and salts derived from β-Lactam antibiotics
Ferraz, Ricardo; Branco, Luís; Marrucho, Isabel; Fernandes, Rúben; Prudêncio, Cristina; Noronha, João Paulo; Petrovski, ZeljkoIn recent years ionic liquids (ILs) have been increasing the popularity and the number of applications. Ionic liquids were used mainly as solvent in organic synthesis, but in recent years they are also used in analytical chemistry, separation chemistry and material science. Additional to significant developments in their chemical properties and applications, ionic liquids are now bringing unexpected opportuniti...
Preparation and characterization of beta-lactam antibiotic as Ionic liquids and...
Ferraz, Ricardo; Fernandes, Rúben; Prudêncio, Cristina; Branco, Luís; Marrucho, Isabel; Noronha, João Paulo; Petrovski, ZeljkoWith the increase of bacterial resistance a large number of therapeutic strategies have been used to fight different kind of infections. In recent years ionic liquids (ILs) have been increasing the popularity and the number of applications. First ionic liquids were used mainly as solvent in organic synthesis, but now they are used in analytical chemistry, separation chemistry and material science among others. ...