26 documents found, page 1 of 3
Thyroid cancer: The quest for genetic susceptibility involving dna repair genes
Santos, LS; Gomes, BC; Bastos, HN; Gil, OM; Azevedo, AP; Ferreira, TC; Limbert, E; Silva, SN; Rueff, JThe incidence of thyroid cancer (TC), particularly well-differentiated forms (DTC), has been rising and remains the highest among endocrine malignancies. Although ionizing radiation (IR) is well established on DTC aetiology, other environmental and genetic factors may also be involved. DNA repair single nucleotide polymorphisms (SNPs) could be among the former, helping in explaining the high incidence. To furth...
The Na+ -Coupled Glucose Transporter SGLT2 Interacts with its Accessory Unit MA...
Calado, J; Santos, AR; Aires, I; Lebre, F; Nolasco, F; Rueff, J; Ramalho, JNa+ -glucose cotransporter 2 is the renal Na+ -coupled glucose transporter responsible for the tubular glucose reabsorption, while MAP17 was recently identified as its accessory unit. Mutations in either of the proteins' coding genes, SLC5A2 and PDZK1IP1, lead to urinary glucose excretion. To investigate whether MAP17 interacts with SGLT2 in vitro, we engineered a V5-tagged SGLT2 construct and evaluated HEK293T...
Prognostic Value of MicroRNA-203a Expression in Breast Cancer
Costa Gomes, B; Martins, M; Lopes, P; Morujão, I; Oliveira, M; Araújo, A; Rueff, J; Rodrigues, ASTumor heterogeneity and the poor outcome of breast cancer (BC) patients have led researchers to define new markers of this disease. In recent years, microRNA expression patterns have proven to be valuable disease indicators. The level of miR-203a, in particular, was shown to be altered in different types of cancer. The objective of the present study was to assess the relationship between miR-203a expression and...
Disruption of Urate Transport in Familial Renal Glucosuria and Report on SGLT2 ...
Aires, I; Santos, AR; Bogarin, R; Genc, G; Pratas, J; Ozkaya, O; Carvalho, F; Rueff, J; Nolasco, F; Calado, JFamilial renal glucosuria (FRG) is a rare co -dominantly inherited benign phenotype characterized by the presence of glucose in the urine. It is caused by mutations in the SLC5A2 gene that encodes SGLT2, a Na+ -glucose co -transporter. The purpose of our current work was twofold: to characterize the molecular and phenotype findings of an FRG cohort and, in addition, to detail the SGLT2 expression in the adult h...
Cytotoxicity evaluation of shellfish extracts naturally contaminated with diarr...
Rodrigues, SM; Vale, P; Chaveca, T; Rueff, J; Oliveira, NG
Evaluation of the protective effect of superoxide scavengers on the cytotoxicit...
Fernandes, AS; Gaspar, J; Cabral, MF; Serejo, J; Bettencourt, A; Rueff, J; Castro, M; Costa, J; Oliveira, NG
Glycidamide-DNA adducts and sister chromatid exchanges in human lymphocytes exp...
Pingarilho, M; Martins, C; Oliveira, NG; Vaz, S; Gamboa da Costa, G; Martins, V; Marques, MM; Beland, FA; Churchwell, MI; Doerge, DR; Rueff, J
Pyridine-containing macrocyclic copper (II) complexes
Fernandes, AS; Oliveira, N; Gaspar, JF; Cabral, MF; Caneiras, C; Rueff, J; Castro, M; Costa, J
Evaluation of the effect of MnTMPyP on the cytotoxicity induced by different ox...
Fernandes, AS; Gaspar, JF; Cabral, MF; Bettencourt, AF; Caneiras, C; Rueff, J; Castro, M; Costa, J; Oliveira, NG
Induction of sister-chromatid exchanges and chromosomal aberrations by acrylami...
Martins, C; Gaspar, J; Martins, V; Gamboa da Costa, G; Marques, MM; Rueff, J; Oliveira, NG