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Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma

Buettner, S; Ten Cate, D; Bagante, F; Alexandrescu, S; Pinto Marques, H; Lamelas, J; Aldrighetti, L; Gamblin, T; Maithel, S; Pulitano, C; Margonis, G

Background: Multiple tumor foci of intrahepatic cholangiocarcinoma (ICC) are often considered a contra-indication for resection. We sought to define long-term outcomes after resection of ICC in patients with multiple foci. Methods: Patients who underwent resection for ICC between 1990 and 2017 were identified from 12 major HPB centers. Outcomes of patients with solitary lesions, multiple lesions (ML), and oligo...


A Multi-Institutional Analysis of Elderly Patients Undergoing a Liver Resection...

Vitale, A; Spolverato, G; Bagante, F; Gani, F; Popescu, I; Pinto Marques, H; Aldrighetti, L; Gamblin, TC; Maithel, S; Sandroussi, C; Bauer, T; Shen, F

BACKGROUND: Little is known regarding postoperative outcomes of elderly patients undergoing liver surgery for intrahepatic cholangiocarcinoma (ICC). METHODS: Five hundred and eighty-four patients undergoing liver resection for ICC between 1990 and 2015 were identified. Perioperative morbidity, mortality, overall survival (OS), and disease-free survival (DFS) were compared between elderly (>70 year, n = 129) and...


Defining When to Offer Operative Treatment for Intrahepatic Cholangiocarcinoma:...

Bagante, F; Spolverato, G; Cucchetti, A; Gani, F; Popescu, I; Ruzzenente, A; Pinto Marques, H; Aldrighetti, L; Gamblin, T; Maithel, S; Sandroussi, C

BACKGROUND: Regret-based decision curve analysis (DCA) is a framework that assesses the medical decision process according to physician attitudes (expected regret) relative to disease-based factors. We sought to apply this methodology to decisions around the operative management of intrahepatic cholangiocarcinoma (ICC). METHODS: Utilizing a multicentric database of 799 patients who underwent liver resection for...


Recurrence After Operative Management of Intrahepatic Cholangiocarcinoma

Hyder, O; Hatzaras, I; Sotiropoulos, G; Paul, A; Alexandrescu, S; Marques, H; Pulitano, C; Barroso, E; Clary, B; Aldrighetti, L; Ferrone, C; Zhu, A

INTRODUCTION: Data on recurrence after operation for intrahepatic cholangiocarcinoma (ICC) are limited. We sought to investigate rates and patterns of recurrence in patients after operative intervention for ICC. METHODS: We identified 301 patients who underwent operation for ICC between 1990 and 2011 from an international, multi-institutional database. Clinicopathologic data, recurrence patterns, and recurrence...


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