2 documents found, page 1 of 1
Association of vitamin D receptor gene polymorphisms with rheumatoid arthritis
Pete, NM; Ramírez, CP; Montoro, MDM; Martínez, F; Fernández-Llimos, F; Pozo, AS; Tortosa, MDR; Morales, AJIntroduction: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown etiology which causes progressive deterioration of the joints, leading to severe pain and functional disability. Vitamin D and its receptor (VDR) play a significant part in the onset of autoimmune diseases such as RA. The purpose of this study was to evaluate the association between VDR gene polymorphisms and risk of...
Dynamism, sensitivity, and consequences of mesenchymal and stem-like phenotype ...
Gener, P; Seras-Franzoso, J; Callejo, P; Andrade, F; Rafael, D; Martínez, F; Montero, S; Arango, D; Sayós, J; Abasolo, I; Schwartz, SThere are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch between CSC and non-CSC phenotypes and vice versa, to ensure the necessary balance within the tumor. Likewise, cancer c...