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BD-2 and BD-3 Increase Skin Flap Survival in a Model of Ischemia and Pseudomona...
Casal, D; Iria, I; Ramalho, JS; Alves, S; Mota-Silva, E; Mascarenhas-Lemos, L; Pontinha, C; Guadalupe-Cabral, M; Ferreira-Silva, J; Ferraz-Oliveira, MThe main aim of this work was to study the usefulness of human β-defensins 2 (BD-2) and 3 (BD-3), which are part of the innate immune system, in the treatment of infected ischemic skin flaps. We investigated the effect of transducing rat ischemic skin flaps with lentiviral vectors encoding human BD-2, BD-3, or both BD-2 and BD-3, to increase flap survival in the context of a P. aeruginosa infection associated w...
A Model of Free Tissue Transfer: The Rat Epigastric Free Flap
Casal, D; Pais, D; Iria, I; Mota-Silva, E; Almeida, MA; Alves, S; Pen, C; Farinho, A; Mascarenhas-Lemos, L; Ferreira-Silva, J; Ferraz-Oliveira, MFree tissue transfer has been increasingly used in clinical practice since the 1970s, allowing reconstruction of complex and otherwise untreatable defects resulting from tumor extirpation, trauma, infections, malformations or burns. Free flaps are particularly useful for reconstructing highly complex anatomical regions, like those of the head and neck, the hand, the foot and the perineum. Moreover, basic and tr...