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The percentage of −2 pro–prostate-specific antigen and the prostate health inde...

Garrido, Manuel Matos; Marta, José C.; Bernardino, Rui M.; Guerra, João; Fernandes, Francisco; Pereira, Maria H.; Ribeiro, Ruy; Holdenrieder, Stefan

Context.—: There is a need to avoid the overdiagnosis of prostate cancer (PCa) and to find more specific biomarkers. Objective.—: To evaluate the clinical utility of [-2]pro-prostate-specific antigen ([-2]proPSA) derivatives in detecting clinically significant PCa (csPCa) and to compare it with prostate-specific antigen (PSA) and with the percentage of free PSA (%fPSA). Design.—: Two hundred thirty-seven men (P...


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