16 documents found, page 1 of 2
Coffee Pulp from Azores: A Novel Phytochemical-Rich Food with Potential Anti-Di...
Costa, Anabela S.G.; Peixoto, Juliana A. Barreto; Machado, Susana; Santo, Liliana Espírito; Soares, Thiago F.; Andrade, Nelson; Azevedo, RuiCoffee pulp, a by-product of wet coffee processing, shows significant potential in the food and health domains, but its real applications remain underexplored. This work investigated the chemical composition and bioactive properties of coffee pulp from São Miguel Island (Azores, Portugal). The studied coffee pulp exhibited high fiber content (52% dw), mostly insoluble; notable mineral levels (10.6%), mainly K, ...
Valorizing coffee silverskin based on its phytochemicals and antidiabetic poten...
Peixoto, Juliana A. Barreto; Andrade, Nelson; Machado, Susana; Costa, Anabela S. G.; Puga, Hélder; Oliveira, Maria Beatriz P. P.; Martel, FátimaThis study investigates the possibility of valorizing coffee silverskin through the recovery of its bioactive compounds using a sustainable extraction method that could be industrially applied. For that, aqueous extracts were prepared using ultrasonic-assisted extraction (laboratorial scale) and, for comparison, a scale-up of the process was developed using the Multi-frequency Multimode Modulated technology. A ...
Increasing the potential of cell-penetrating peptides for cancer therapy using ...
Duarte, Diana; Fraga, Alexandra Gabriel; Pedrosa, Jorge; Martel, Fátima; Vale, NunoCancer treatment is one of the major fields of interest for the scientific community. Investment in cancer research is costly but essential to provide patients with more effective and safe treatments. In this project, we describe the synthesis and characterization of new thiazole derivatives coupled to CPP2, a cell-penetrating peptide (CPP) reported for colon cancer cells. Using a human adenocarcinoma-derived c...
Development of novel Cu(I) compounds with vitamin B1 derivative and their poten...
Brandão, Paula; Guieu, Samuel; Correia-Branco, Ana; Silva, Cláudia; Martel, FátimaThe synthesis and crystal structure of two new copper(I) compounds with molecular formula of {Cu4[(µ3-thiocrome)2Cl4]∙2(H2O)}n 1, and Cu2[(µ2-thiocrome)2Cl2] 2 are reported. The crystal structure of compounds 1 and 2 are solved by single crystal X-ray diffraction. The reaction of Cu(II) with thiamine chloride in water at room temperature produces Cu(I) thiochrome compounds 1 and 2. Compound 1 shows a 1D chain s...
Modulation of the uptake of critical nutrients by breast cancer cells by lactat...
Guedes, Marta; Araújo, João R.; Correia-Branco, Ana; Gregório, Inês; Martel, Fátima; Keating, ElisaThis work aimed to characterize the uptake of folate and glucose by breast cancer cells and to study the effect of lactate upon the transport of these nutrients and upon cell viability, proliferation and migration capacity. Data obtained showed that: a) MCF7 cells uptake (3)H-folic acid ((3)H-FA) at physiological but not at acidic pH; b) T47D cells accumulate (3)H-FA and (14)C-5-methyltetrahydrofolate ((14)C-5-...
Modulation of the uptake of critical nutrients by breast cancer cells by lactat...
Guedes, Marta; Araújo, João R.; Correia-Branco, Ana; Gregório, Inês; Martel, Fátima; Keating, ElisaThis work aimed to characterize the uptake of folate and glucose by breast cancer cells and to study the effect of lactate upon the transport of these nutrients and upon cell viability, proliferation and migration capacity. Data obtained showed that: a) MCF7 cells uptake (3)H-folic acid ((3)H-FA) at physiological but not at acidic pH; b) T47D cells accumulate (3)H-FA and (14)C-5-methyltetrahydrofolate ((14)C-5-...
Synthesis, structural characterization, cytotoxic properties and DNA binding of...
Leite Ferreira, B. J. M.; Brandao, P.; Meireles, M.; Martel, Fátima; Correia-Branco, Ana; Fernandes, Diana M.; Santos, T. M.; Felix, V.In this study a novel dinuclear copper(II) complex with adenine and phenanthroline has been synthesized and its structure determined by single crystal X-ray diffraction. In the dinuclear complex [Cu-2(mu-adenine)(2)(phen)(2)(H2O)2](NO3)(4)center dot 0.5H(2)O (phen = 1,10-phenanthroline) (1) the two Cu(II) centres exhibit a distorted square pyramidal coordination geometry linked by two nitrogen donors from adeni...
The chemopreventive effect of the dietary compound kaempferol on the MCF-7 huma...
Azevedo, Cláudia; Correia-Branco, Ana; Araújo, João R.; Guimarães, João T.; Keating, Elisa; Martel, FátimaOur aim was to investigate the effect of several dietary polyphenols on glucose uptake by breast cancer cells. Uptake of H-3-deoxy-D-glucose (H-3-DG) by MCF-7 cells was time-dependent, saturable, and inhibited by cytochalasin B plus phloridzin. In the short-term (26min), myricetin, chrysin, genistein, resveratrol, kaempferol, and xanthohumol (10-100 mu M) inhibited H-3-DG uptake. Kaempferol was found to be the ...
Excess perigestational folic acid exposure induces metabolic dysfunction in pos...
Keating, Elisa; Correia-Branco, Ana; Araújo, João R,; Meireles, Manuela; Fernandes, Rita; Guardão, Luísa; Guimarães, João T.; Martel, FátimaThe aim of this study was to understand whether high folic acid (HFA) exposure during the perigestational period induces metabolic dysfunction in the offspring, later in life. To do this, female Sprague-Dawley rats (G0) were administered a dose of folic acid (FA) recommended for pregnancy (control, C, 2 mg FA/kg of diet, n=5) or a high dose of FA (HFA, 40 mg FA/kg of diet, n=5). Supplementation began at mating ...
Maternal undernutrition and fetal developmental programming of obesity: the glu...
Correia-Branco, Ana; Keating, Elisa; Martel, FátimaAn adequatematernal nutrition during pregnancy is crucial for the health outcome of offspring in adulthood. Maternal undernutrition during critical periods of fetal development can program the fetus for metabolic syndrome (MetS) later in life, especially when postnatally challenged with a hypernutritive diet. Adipogenesis, which begins in utero and accelerates in neonatal life, is a major candidate for developm...