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Morin-loaded chitosan-poloxamer hydrogel as an osteoinductive delivery system f...
Pereira, Jesse Augusto; Martin, Victor; Araújo, Rita; Grenho, Liliana; Gomes, Pedro; Marto, Joana; Fernandes, Maria Helena; Santos, CatarinaConsidering the search for new biocompatible intracanal medicaments that can preserve remaining cells and stimulate bone tissue repair in the periapical region, this study aimed to synthesize and characterize the physicochemical properties of morin-loaded chitosan-poloxamer hydrogel (MCP) as well as to evaluate its osteogenic potential. Morin hydrate (M) was loaded into chitosan-poloxamer (CP) hydrogel and the ...
Bonding antimicrobial rhamnolipids onto medical grade PDMS: A strategy to overc...
Dardouri, Maïssa; Aljnadi, Israa M.; Deuermeier, Jonas; Santos, Catarina; Costa, Fabiola; Martin, Victor; Fernandes, Maria H.; Gonçalves, LídiaIn clinic there is a demand to solve the drawback of medical devices multispecies related infections. Consequently, different biomaterial surfaces, such as vascular catheters, urgently need improvement regarding their antifouling/antimicrobial properties. In this work, we covalently functionalized medical grade polydimethylsiloxane (PDMS) with antimicrobial rhamnolipids to investigate the biomaterial surface ac...
A new ex vivo model of the bone tissue response to the hyperglycemic environmen...
Araújo, Rita; Martin, Victor; Ferreira, Rita; Fernandes, Maria Helena; Gomes, Pedro SousaDiabetes mellitus (DM) embrace a group of chronic metabolic conditions with a high morbidity, causing deleterious effects in different tissues and organs, including bone. Hyperglycemia seems to be one of the most contributing etiological factors of bone-related alterations, altering metabolic functionality and inducing morphological adaptations. Despite the established models for the assessment of bone function...
Engineering a multifunctional 3D-printed PLA-collagen-minocycline-nanoHydroxyap...
Martin, Victor; Ribeiro, Isabel A. C.; Alves, Marta M.; Gonçalves, Lídia; Claudio, Ricardo A.; Grenho, Liliana; Fernandes, Maria H.; Gomes, Pedro3D-printing and additive manufacturing can be powerful techniques to design customized structures and produce synthetic bone grafts with multifunctional effects suitable for bone repair. In our work we aimed the development of novel multifunctionalized 3D printed poly(lactic acid) (PLA) scaffolds with bioinspired surface coatings able to reduce bacterial biofilm formation while favoring human bone marrow-derive...
Understanding intracellular trafficking and anti-inflammatory effects of minocy...
Martin, Victor; Ribeiro, Isabel A. C.; Alves, Marta M.; Gonçalves, Lídia; Almeida, António José; Grenho, Liliana; Fernandes, Maria H.Periodontal diseases remain a challenge due to a complex interplay of factors involving a chronic inflammatory activation and bacteria internalization in periodontal cells. In this work, chitosan-nanoparticles loaded with minocycline (MH-NPs), a tetracycline with antimicrobial and anti-inflammatory effects, were developed for in situ delivery in the periodontal milieu aiming to improve drug effectiveness. A gen...